一种用于肺癌成像的超顺磁性氧化铁纳米颗粒表面修饰的新策略。

Gang Huang, Chunfu Zhang, Shunzi Li, Chalermchai Khemtong, Su-Geun Yang, Ruhai Tian, John D Minna, Kathlynn C Brown, Jinming Gao
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引用次数: 82

摘要

超顺磁性氧化铁(SPIO)纳米颗粒作为一种多功能的超灵敏纳米探针,广泛应用于磁共振成像(MRI)中,用于癌症的细胞和分子成像。在这项研究中,我们报道了SPIO纳米颗粒与肺癌靶向肽表面功能化的一步程序。合成的SPIO上的疏水表面活性剂通过配体交换被含有聚乙二醇系链半胱氨酸残基的肽取代。所得的SPIO粒子具有生物相容性,并表现出高的T(2)弛豫性。经磁共振成像和普鲁士蓝染色证实,纳米探针对表达α(v)β(6)的肺癌细胞具有特异性。这种简单的表面化学和所提出的SPIO系统的功能设计可能为肺癌的分子诊断提供强大的纳米平台。
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A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.

Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T(2) relaxivity. The nanoprobes are specific in targeting α(v)β(6)-expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.

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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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