[棉酚不对称醛衍生物的合成、结构和急性毒性]。

Bioorganicheskaia khimiia Pub Date : 2010-05-01
K Z Tiliabaev, F G Kamaev, N L Vypova, A M Iuldashev, B T Ibragimov, S A Talipov
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引用次数: 0

摘要

以氨水、苯胺、4-氨基安替比林和巴比妥酸为原料,合成了棉籽黄色多酚色素棉酚的不对称醛类衍生物。采用紫外分光光度法、红外光谱法和(1)氢核磁共振光谱法测定了它们的结构。并与棉酚及其相应的对称类似物对小白鼠的急性毒性进行了比较。结果表明,一般情况下,含棉酚衍生物的游离醛越少,其急性毒性越低。只有在含有4-氨基安替比林残基的非对称棉酚衍生物的情况下,我们才观察到与上述相关性的偏差:其对称对应物的毒性甚至更大,但毒性仍然比棉酚小。
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[Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives].

Nonsymmetrical aldehyde derivatives of gossypol, a yellow polyphenolic pigment of cottonseed, were synthesized by reactions with ammonia, aniline, 4-aminoantipyrine, and barbituric acid. Their structures were determined by UV spectrophotometry and IR and (1)H NMR spectroscopy methods. Their acute toxicities in white mice were compared with those of gossypol and the corresponding symmetrical analogues. It was demonstrated that in general, the fewer free aldehyde groups that contained the gossypol derivative, the lower its acute toxicity. Only in the case of a nonsymmetrical gossypol derivative bearing a 4-aminoantipyrine residue did we observe a deviation from the above correlation: its symmetrical counterpart was even more toxic, but still less toxic than gossypol.

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