Changwon Kho, Ahyoung Lee, Dongtak Jeong, Roger J. Hajjar
{"title":"补充细胞内钙储存","authors":"Changwon Kho, Ahyoung Lee, Dongtak Jeong, Roger J. Hajjar","doi":"10.1016/j.ddmec.2010.08.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Within the cardiac cell, the movements of calcium ions<span> are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts lead to abnormal Ca</span></span><sup>2+</sup><span> homeostasis and consequently to a deficient contractile state. This review focuses on the roles of SR Ca</span><sup>2+</sup> regulators in disease states and novel strategies for therapeutic targeting of these pathways.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 2","pages":"Pages e145-e150"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.004","citationCount":"5","resultStr":"{\"title\":\"Refilling intracellular calcium stores\",\"authors\":\"Changwon Kho, Ahyoung Lee, Dongtak Jeong, Roger J. Hajjar\",\"doi\":\"10.1016/j.ddmec.2010.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Within the cardiac cell, the movements of calcium ions<span> are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts lead to abnormal Ca</span></span><sup>2+</sup><span> homeostasis and consequently to a deficient contractile state. This review focuses on the roles of SR Ca</span><sup>2+</sup> regulators in disease states and novel strategies for therapeutic targeting of these pathways.</p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"7 2\",\"pages\":\"Pages e145-e150\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.004\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676510000210\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts lead to abnormal Ca2+ homeostasis and consequently to a deficient contractile state. This review focuses on the roles of SR Ca2+ regulators in disease states and novel strategies for therapeutic targeting of these pathways.
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