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引用次数: 71
摘要
自从出现耐氯喹的恶性疟原虫和关于寄生虫对替代药物耐药的报道以来，人们对吖啶酮及其同族物吖啶酮的抗疟疾活性重新产生了兴趣。本文综述了天然吖啶酮类生物碱及合成的具有抗疟活性的9-取代吖啶酮、吖啶二酮、卤代氧基吖啶酮和10- n -取代吖啶酮类生物碱的文献汇编。本文还对所述化合物的抗疟疾作用方式进行了展望。
Acridine and acridinones: old and new structures with antimalarial activity.
Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This article presents literature compilation of natural acridinone alkaloids and synthetic 9-substituted acridines, acridinediones, haloalcoxyacridinones and 10-N-substituted acridinones with antimalarial activity. The review also provides an outlook to antimalarial modes of action of some described compounds.
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