分子细胞生物学能解释染色体运动吗?

Daniel H Shain, L John Gagliardi
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引用次数: 3

摘要

背景:有丝分裂染色体的运动最近与静电力相关,但一个挥之不去的“分子细胞生物学”范式仍然存在,提出结合和释放蛋白质或分子几何形状的力量产生。结果:经典静电作用下,极面着丝点板带正电荷并与带负电荷的微管端相互作用,为染色体向极运动提供动力。这一概念方案解释了着丝点与微管的动态跟踪/耦合以及在产生极性力时着丝点微管的同时解聚。结论:我们在这里提出疑问,当已知束缚电荷分布之间的直接静电相互作用可以更简单地完成相同的任务时,为什么细胞更喜欢复杂的分子机制来移动染色体?
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Can molecular cell biology explain chromosome motions?

Background: Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering "molecular cell biology" paradigm persists, proposing binding and release proteins or molecular geometries for force generation.

Results: Pole-facing kinetochore plates manifest positive charges and interact with negatively charged microtubule ends providing the motive force for poleward chromosome motions by classical electrostatics. This conceptual scheme explains dynamic tracking/coupling of kinetochores to microtubules and the simultaneous depolymerization of kinetochore microtubules as poleward force is generated.

Conclusion: We question here why cells would prefer complex molecular mechanisms to move chromosomes when direct electrostatic interactions between known bound charge distributions can accomplish the same task much more simply.

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Theoretical Biology and Medical Modelling
Theoretical Biology and Medical Modelling MATHEMATICAL & COMPUTATIONAL BIOLOGY-
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6-12 weeks
期刊介绍: Theoretical Biology and Medical Modelling is an open access peer-reviewed journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine. Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which Theoretical Biology and Medical Modelling operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.
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