在2007年基于人群的国家FINRISK研究中,每天晚上的睡眠类型与当前吸烟、尼古丁依赖和尼古丁摄入量有关。

Ulla Broms, Marjaana Pennanen, Kristiina Patja, Hanna Ollila, Tellervo Korhonen, Aino Kankaanpää, Ari Haukkala, Annamari Tuulio-Henriksson, Markku Koskenvuo, Erkki Kronholm, Tiina Laatikainen, Markku Peltonen, Timo Partonen, Jaakko Kaprio
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MEASUREMENTS: Diurnal type assessed with a six-item sum scale was categorized as morning, intermediate and evening type. Smoking status was determined as current (daily or occasional), former, and never smokers. ND was measured with the Fagerström Test for Nicotine Dependence (FTND), the Hooked on Nicotine Checklist (HONC), and the Nicotine Dependence Syndrome Scale (NDSS). For current smokers, plasma cotinine was analyzed as biochemical measurement of nicotine intake. FINDINGS: Evening type was associated with current smoking (OR=1.66, 95% CI 1.40, 1.97). A significant association with diurnal type was seen for FTND among men (beta= -0.46, 95% CI -0.72, -0.21), sexes combined for HONC (beta= -0.31, 95% CI -0.52, -0.11) and NDSS (beta= -0.86, 95% CI -1.43, -0.29) and for cotinine among men (beta= -0.73, 95% CI -1.16, -0.29). Adjustment for depressive symptoms attenuated the association of diurnal type with NDSS to be non-significant. 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引用次数: 36

摘要

目的:探讨吸烟习惯、尼古丁依赖(ND)和血浆可替宁水平是否因日型而异。设计:数据来源于2007年全国FINRISK调查。计算回归分析以检验日类型与吸烟状况、ND和尼古丁摄入量之间的关系。参与者:7091名有吸烟和日类型信息的FINRISK参与者和1746名有详细吸烟和ND评估的曾经吸烟者。测量方法:以六项总和量表评估日类型,分为早晨、中间和晚上类型。吸烟状况分为现在吸烟(每天或偶尔吸烟)、曾经吸烟和从不吸烟。使用Fagerström尼古丁依赖测试(FTND)、尼古丁成瘾检查表(HONC)和尼古丁依赖综合征量表(NDSS)测量尼古丁依赖。对于当前吸烟者,血浆可替宁作为尼古丁摄入量的生化指标进行分析。发现:夜型与当前吸烟相关(OR=1.66, 95% CI 1.40, 1.97)。男性FTND (β = -0.46, 95% CI -0.72, -0.21)、HONC (β = -0.31, 95% CI -0.52, -0.11)和NDSS (β = -0.86, 95% CI -1.43, -0.29)和男性可替宁(β = -0.73, 95% CI -1.16, -0.29)与昼夜类型显著相关。对抑郁症状进行调整后,昼夜类型与NDSS的关联减弱至不显著。结论:日类型与多项ND测量和尼古丁摄入量相关,有趣的是,在男性中更为明显。夜猫子依赖的风险更高,但抑郁症状明显减弱了这种关联。
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Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study.

AIMS: To examine whether smoking habits, nicotine dependence (ND) and plasma cotinine levels differ by diurnal type. DESIGN: Data originated from the national FINRISK 2007 survey. Regression analyses were calculated to examine the association between diurnal type and smoking status, ND, and nicotine intake. PARTICIPANTS: 7091 FINRISK participants with smoking and diurnal type information and a subset of 1746 ever smokers with detailed smoking, and ND assessments. MEASUREMENTS: Diurnal type assessed with a six-item sum scale was categorized as morning, intermediate and evening type. Smoking status was determined as current (daily or occasional), former, and never smokers. ND was measured with the Fagerström Test for Nicotine Dependence (FTND), the Hooked on Nicotine Checklist (HONC), and the Nicotine Dependence Syndrome Scale (NDSS). For current smokers, plasma cotinine was analyzed as biochemical measurement of nicotine intake. FINDINGS: Evening type was associated with current smoking (OR=1.66, 95% CI 1.40, 1.97). A significant association with diurnal type was seen for FTND among men (beta= -0.46, 95% CI -0.72, -0.21), sexes combined for HONC (beta= -0.31, 95% CI -0.52, -0.11) and NDSS (beta= -0.86, 95% CI -1.43, -0.29) and for cotinine among men (beta= -0.73, 95% CI -1.16, -0.29). Adjustment for depressive symptoms attenuated the association of diurnal type with NDSS to be non-significant. CONCLUSIONS: Diurnal type was associated with multiple ND measures and nicotine intake, interestingly more so among men. Evening type persons are at higher risk of dependence, but depressive symptoms attenuates this association clearly.

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