通过溶剂诱导相分离(SIPS)调整PEG-DA水凝胶性质()。

Journal of Materials Chemistry Pub Date : 2011-01-01 Epub Date: 2011-10-21 DOI:10.1039/C1JM13943F
Brennan Margaret Bailey, Vivian Hui, Ruochong Fei, Melissa Ann Grunlan
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引用次数: 19

摘要

聚乙二醇二丙烯酸酯(PEG-DA)水凝胶被广泛用于探测细胞-物质相互作用,并最终用于材料引导的组织再生方法。在本研究中,通过溶剂诱导相分离(SIPS)制备PEG-DA水凝胶,获得具有更广泛可调物理性质的水凝胶,包括形态(例如孔隙度),膨胀和模量(G')。与传统的由水前驱体溶液制备的PEG-DA水凝胶不同,SIPS方案使用了二氯甲烷(DCM)前驱体溶液,该前驱体溶液依次进行光聚合、干燥和水化。通过改变PEG-DA wt%浓度(5 wt%-25 wt%)和M(n) (3.4k和6k g mol(-1)),进一步调整其物理性质。SIPS生产的PEG-DA水凝胶具有大孔形态,与相应的常规PEG-DA水凝胶相比,G′值增加。值得注意的是,由于总的肿胀与相应的常规PEG-DA水凝胶相比没有明显变化,因此成对或系列的水凝胶代表了形态和水化或G′和水化不耦合的支架。此外,通过SIPS制备的PEG-DA水凝胶的降解率也有所提高。
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Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS)().

Poly(ethylene glycol) diacrylate (PEG-DA) hydrogels are widely utilized to probe cell-material interactions and ultimately for a material-guided approach to tissue regeneration. In this study, PEG-DA hydrogels were fabricated via solvent-induced phase separation (SIPS) to obtain hydrogels with a broader range of tunable physical properties including morphology (e.g. porosity), swelling and modulus (G'). In contrast to conventional PEG-DA hydrogels prepared from an aqueous precursor solution, the reported SIPS protocol utilized a dichloromethane (DCM) precursor solution which was sequentially photopolymerized, dried and hydrated. Physical properties were further tailored by varying the PEG-DA wt% concentration (5 wt%-25 wt%) and M(n) (3.4k and 6k g mol (-1)). SIPS produced PEG-DA hydrogels with a macroporous morphology as well as increased G' values versus the corresponding conventional PEG-DA hydrogels. Notably, since the total swelling was not significantly changed versus the corresponding conventional PEG-DA hydrogels, pairs or series of hydrogels represent scaffolds in which morphology and hydration or G' and hydration are uncoupled. In addition, PEG-DA hydrogels prepared via SIPS exhibited enhanced degradation rates.

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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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