Epithelial downgrowth: an atypical clinicopathological case report.

To The Editor Epithelial downgrowth is a rare but grave complication of intraocular surgery,1,2 that typically presents as epithelial sheets, cysts, or pearls1,2,3,4. Prognosis is poor as incursion of epithelial cells onto anterior chamber structures can result in corneal decompensation, refractory glaucoma, and visual deficits2. Treatment options include enucleation, surgical excision, irradiation, cryotherapy, cautery, laser coagulation, vitrectomy and injections of antimetabolites1,2,3,4,5. The present report describes a case in which epithelial downgrowth presented as an amorphous anterior chamber cellular aggregate, was diagnosed by anterior chamber tap and specular microscopy, and was treated successfully with 5-Fluorouracil.