缺血后大鼠脑血管内皮生长因子- b的表达。

Q4 Neuroscience Vascular Cell Pub Date : 2013-04-20 eCollection Date: 2013-01-01 DOI:10.1186/2045-824X-5-8

Lin Xie, Xiaoou Mao, Kunlin Jin, David A Greenberg

{"title":"缺血后大鼠脑血管内皮生长因子- b的表达。","authors":"Lin Xie, Xiaoou Mao, Kunlin Jin, David A Greenberg","doi":"10.1186/2045-824X-5-8","DOIUrl":null,"url":null,"abstract":"Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.Methods: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.","PeriodicalId":23948,"journal":{"name":"Vascular Cell","volume":"5 ","pages":"8"},"PeriodicalIF":0.0000,"publicationDate":"2013-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2045-824X-5-8","citationCount":"24","resultStr":"{\"title\":\"Vascular endothelial growth factor-B expression in postischemic rat brain.\",\"authors\":\"Lin Xie, Xiaoou Mao, Kunlin Jin, David A Greenberg\",\"doi\":\"10.1186/2045-824X-5-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.Methods: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.\",\"PeriodicalId\":23948,\"journal\":{\"name\":\"Vascular Cell\",\"volume\":\"5 \",\"pages\":\"8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/2045-824X-5-8\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vascular Cell\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/2045-824X-5-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2013/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/2045-824X-5-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}

引用次数: 24

摘要

背景:血管内皮生长因子- b (VEGF-B)对实验性脑卒中具有保护作用，但脑卒中对VEGF-B表达的影响尚不确定。方法:采用免疫组化方法检测大鼠大脑中动脉闭塞后1 ~ 7 d缺血边缘区VEGF-B的表达。结果:大脑中动脉闭塞后边缘区VEGF-B免疫反应性升高，与神经元和巨噬细胞/小胶质细胞相关，与星形胶质细胞和内皮细胞无关。结论:这些发现为VEGF-B在脑缺血内源性反应中的作用提供了额外的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Vascular endothelial growth factor-B expression in postischemic rat brain.

Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.

Methods: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.

Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.

Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊