人内源性逆转录病毒(HERVs)与自身免疫性风湿病:有联系吗?

Q4 Medicine Open Rheumatology Journal Pub Date : 2013-03-22 Print Date: 2013-01-01 DOI:10.2174/1874312901307010013

Nicola Tugnet, Paul Rylance, Denise Roden, Malgorzata Trela, Paul Nelson

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引用次数: 69

摘要

自身免疫性风湿性疾病，如风湿性关节炎和SLE，是由遗传、激素和环境因素引起的。人内源性逆转录病毒(HERVs)可能是自身免疫性风湿病的触发因素。herv是一种化石病毒，大约在3000万至4000万年前开始被整合到人类基因组中，现在占基因组的8%。有证据表明，herv可能导致RA和SLE，以及其他风湿病。假设HERVS导致疾病的关键机制包括分子模仿和免疫失调。在类风湿性关节炎和系统性红斑狼疮中发现herv可能会为这些慢性疾病带来新的治疗方法。本文综述了herv作为自身免疫性风湿病的诱因的证据，并讨论了其临床意义和发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human Endogenous Retroviruses (HERVs) and Autoimmune Rheumatic Disease: Is There a Link?

Autoimmune rheumatic diseases, such as RA and SLE, are caused by genetic, hormonal and environmental factors. Human Endogenous Retroviruses (HERVs) may be triggers of autoimmune rheumatic disease. HERVs are fossil viruses that began to be integrated into the human genome some 30-40 million years ago and now make up 8% of the genome. Evidence suggests HERVs may cause RA and SLE, among other rheumatic diseases. The key mechanisms by which HERVS are postulated to cause disease include molecular mimicry and immune dysregulation. Identification of HERVs in RA and SLE could lead to novel treatments for these chronic conditions. This review summarises the evidence for HERVs as contributors to autoimmune rheumatic disease and the clinical implications and mechanisms of pathogenesis are discussed.

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来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

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0.00%

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