Honglv Xu , Xiaoyan Wu , Chunmei Liang , Jie Shen , Shuman Tao , Xing Wen , Wenwen Liu , Liwei Zou , Yajuan Yang , Yang Xie , Zhongxiu Jin , Tingting Li , Fangbiao Tao
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Concentration of six phthalate metabolites in urine was determined by high-performance liquid chromatography-tandem mass spectrometry and the emotional symptoms were assessed by the 21-item Depression, Anxiety, and Stress Scale. The detection rate of six phthalate metabolites in urine ranged from 79.6% to 99.7%. The median concentration of six phthalate metabolites ranged from 2.90 to 119.64 ng/mL. The positive rates of depressive symptoms, anxiety symptoms, and stress were 17.4%, 24.8%, and 9.5%, respectively. After adjusting for the confounding variables, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was found to be associated with depressive symptoms (</span><em>β</em> = 8.84, <em>P</em> = 0.017), anxiety symptoms (<em>β</em> = 8.46, <em>P</em> = 0.015), and stress symptoms (<em>β</em> = 9.95, <em>P</em> = 0.012) in males; whereas, monobutyl phthalate (MBP) was found to be associated with depressive symptoms (<em>β</em> = 1.86, <em>P</em> = 0.002), anxiety symptoms (<em>β</em> = 1.81, <em>P</em> = 0.005), and stress symptoms (<em>β</em> = 1.48, <em>P</em> = 0.047) in females. Our study demonstrates that Chinese university students are widely exposed to phthalates; and high- and low-molecular weight phthalates are associated with emotional symptoms in males and females, respectively.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6000,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.envpol.2020.114279","citationCount":"13","resultStr":"{\"title\":\"Association of urinary phthalates metabolites concentration with emotional symptoms in Chinese university students\",\"authors\":\"Honglv Xu , Xiaoyan Wu , Chunmei Liang , Jie Shen , Shuman Tao , Xing Wen , Wenwen Liu , Liwei Zou , Yajuan Yang , Yang Xie , Zhongxiu Jin , Tingting Li , Fangbiao Tao\",\"doi\":\"10.1016/j.envpol.2020.114279\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Previous studies have shown the associations between phthalates exposure and psychological behavior problems in children and adolescents, but such associations have not been fully elucidated in university students, especially among Chinese university students. This study aims to examine the association between urinary phthalates metabolites concentration and emotional symptoms in Chinese university students. A school-based cross-sectional survey was carried out among 990 university students aged 17–24 years from two universities in Anhui and Jiangxi provinces of China. Concentration of six phthalate metabolites in urine was determined by high-performance liquid chromatography-tandem mass spectrometry and the emotional symptoms were assessed by the 21-item Depression, Anxiety, and Stress Scale. The detection rate of six phthalate metabolites in urine ranged from 79.6% to 99.7%. The median concentration of six phthalate metabolites ranged from 2.90 to 119.64 ng/mL. The positive rates of depressive symptoms, anxiety symptoms, and stress were 17.4%, 24.8%, and 9.5%, respectively. After adjusting for the confounding variables, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was found to be associated with depressive symptoms (</span><em>β</em> = 8.84, <em>P</em> = 0.017), anxiety symptoms (<em>β</em> = 8.46, <em>P</em> = 0.015), and stress symptoms (<em>β</em> = 9.95, <em>P</em> = 0.012) in males; whereas, monobutyl phthalate (MBP) was found to be associated with depressive symptoms (<em>β</em> = 1.86, <em>P</em> = 0.002), anxiety symptoms (<em>β</em> = 1.81, <em>P</em> = 0.005), and stress symptoms (<em>β</em> = 1.48, <em>P</em> = 0.047) in females. 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引用次数: 13
摘要
以往的研究表明,邻苯二甲酸盐暴露与儿童和青少年的心理行为问题之间存在关联,但这种关联尚未在大学生中得到充分阐明,特别是在中国大学生中。本研究旨在探讨中国大学生尿邻苯二甲酸酯代谢物浓度与情绪症状的关系。本研究以安徽省和江西省两所高校的990名17-24岁大学生为调查对象,进行校本横断面调查。采用高效液相色谱-串联质谱法测定尿中6种邻苯二甲酸酯代谢物的浓度,采用21项抑郁、焦虑和压力量表评估情绪症状。尿中6种邻苯二甲酸酯代谢物的检出率为79.6% ~ 99.7%。6种邻苯二甲酸酯代谢物的中位浓度为2.90 ~ 119.64 ng/mL。抑郁症状阳性率为17.4%,焦虑症状阳性率为24.8%,压力症状阳性率为9.5%。校正混杂变量后,发现邻苯二甲酸酯(MEHHP)与男性抑郁症状(β = 8.84, P = 0.017)、焦虑症状(β = 8.46, P = 0.015)和应激症状(β = 9.95, P = 0.012)相关;而邻苯二甲酸一丁酯(MBP)与女性抑郁症状(β = 1.86, P = 0.002)、焦虑症状(β = 1.81, P = 0.005)和应激症状(β = 1.48, P = 0.047)相关。我们的研究表明,中国大学生广泛暴露于邻苯二甲酸酯;高分子量邻苯二甲酸酯和低分子量邻苯二甲酸酯分别与男性和女性的情绪症状有关。
Association of urinary phthalates metabolites concentration with emotional symptoms in Chinese university students
Previous studies have shown the associations between phthalates exposure and psychological behavior problems in children and adolescents, but such associations have not been fully elucidated in university students, especially among Chinese university students. This study aims to examine the association between urinary phthalates metabolites concentration and emotional symptoms in Chinese university students. A school-based cross-sectional survey was carried out among 990 university students aged 17–24 years from two universities in Anhui and Jiangxi provinces of China. Concentration of six phthalate metabolites in urine was determined by high-performance liquid chromatography-tandem mass spectrometry and the emotional symptoms were assessed by the 21-item Depression, Anxiety, and Stress Scale. The detection rate of six phthalate metabolites in urine ranged from 79.6% to 99.7%. The median concentration of six phthalate metabolites ranged from 2.90 to 119.64 ng/mL. The positive rates of depressive symptoms, anxiety symptoms, and stress were 17.4%, 24.8%, and 9.5%, respectively. After adjusting for the confounding variables, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was found to be associated with depressive symptoms (β = 8.84, P = 0.017), anxiety symptoms (β = 8.46, P = 0.015), and stress symptoms (β = 9.95, P = 0.012) in males; whereas, monobutyl phthalate (MBP) was found to be associated with depressive symptoms (β = 1.86, P = 0.002), anxiety symptoms (β = 1.81, P = 0.005), and stress symptoms (β = 1.48, P = 0.047) in females. Our study demonstrates that Chinese university students are widely exposed to phthalates; and high- and low-molecular weight phthalates are associated with emotional symptoms in males and females, respectively.
期刊介绍:
Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health.
Subject areas include, but are not limited to:
• Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies;
• Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change;
• Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects;
• Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects;
• Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest;
• New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.