Sirtuin 3:肥胖相关代谢疾病的主要控制点?

Drug discovery today. Disease mechanisms Pub Date : 2013-06-01 DOI:10.1016/j.ddmec.2013.04.001

Sean A. Newsom , Kristen E. Boyle , Jacob E. Friedman

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引用次数: 15

摘要

肥胖和肥胖相关并发症是目前困扰许多发达国家的流行病问题，其发病率、死亡率和经济负担都在增加。在这篇简短的综述中，我们讨论了线粒体sirtuin 3作为治疗肥胖相关代谢疾病的治疗靶点的可能作用的新证据和遗留问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sirtuin 3: a major control point for obesity-related metabolic diseases?

Obesity and obesity-related complications are epidemic issues currently plaguing much of the developed world with increasing associated morbidity, mortality, and economic burden. In this brief review, we discuss emerging evidence and remaining questions regarding the possible role for mitochondrial sirtuin 3 as a therapeutic target for the treatment of obesity-related metabolic diseases.

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Drug discovery today. Disease mechanisms

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