噬菌体T5的ssdna结合蛋白的鉴定:对T5复制的意义。

Bacteriophage Pub Date : 2013-10-01 Epub Date: 2013-12-09 DOI:10.4161/bact.27304
Sebastiaan Werten
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引用次数: 8

摘要

在最近的一项研究中,我们鉴定并表征了长期以来难以捉摸的噬菌体T5的复制单链dna结合蛋白,我们发现它与真核生物转录共激活子PC4有关。在这里,我们对这些数据进行了扩展的讨论,报告了一些额外的观察结果,并考虑了对T5属的重组依赖复制机制的影响,这一机制仍然知之甚少。
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Identification of the ssDNA-binding protein of bacteriophage T5: Implications for T5 replication.

In a recent study, we identified and characterized the long-elusive replicative single-stranded DNA-binding protein of bacteriophage T5, which we showed is related to the eukaryotic transcription coactivator PC4. Here, we provide an extended discussion of these data, report several additional observations and consider implications for the recombination-dependent replication mechanism of the T5 genus, which is still poorly understood.

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