Tamina Seeger-Nukpezah, Joy L. Little, Victoria Serzhanova, Erica A. Golemis
{"title":"癌症中的纤毛和纤毛相关蛋白","authors":"Tamina Seeger-Nukpezah, Joy L. Little, Victoria Serzhanova, Erica A. Golemis","doi":"10.1016/j.ddmec.2013.03.004","DOIUrl":null,"url":null,"abstract":"<div><p>The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways<span> and proteins, including mTOR<span>, VHL, TSC, WNT, Aurora-A, NEDD9 and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma<span>, medulloblastoma and breast cancer.</span></span></span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"10 3","pages":"Pages e135-e142"},"PeriodicalIF":0.0000,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2013.03.004","citationCount":"50","resultStr":"{\"title\":\"Cilia and cilia-associated proteins in cancer\",\"authors\":\"Tamina Seeger-Nukpezah, Joy L. Little, Victoria Serzhanova, Erica A. Golemis\",\"doi\":\"10.1016/j.ddmec.2013.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways<span> and proteins, including mTOR<span>, VHL, TSC, WNT, Aurora-A, NEDD9 and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma<span>, medulloblastoma and breast cancer.</span></span></span></p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"10 3\",\"pages\":\"Pages e135-e142\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2013.03.004\",\"citationCount\":\"50\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676513000138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676513000138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins, including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9 and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma and breast cancer.
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