外泌体在促和抗血管生成中的作用。

Mara Fernandes Ribeiro, Hongyan Zhu, Ronald W Millard, Guo-Chang Fan
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引用次数: 135

摘要

外泌体是一组小泡(30-100 nm),当内体膜向内出芽形成多泡体(MVBs)时产生。当MVBs与质膜融合时,外泌体被释放到细胞外空间。大量研究表明外泌体在介导细胞间通讯中起着关键作用。此外,外泌体被认为在调节细胞存活/死亡、炎症和肿瘤转移方面具有强大的能力,这取决于特定外泌体群体中包含的特定分子阵列。本文将总结来自不同类型细胞(即内皮细胞、肿瘤细胞、血小板、骨髓干细胞、心肌细胞、心肌祖细胞等)的外泌体在内皮细胞增殖、迁移和管状细胞形成中的双重作用。特别地,本文将重点介绍外泌体作为一种天然纳米颗粒,将促/抗血管生成因子(蛋白质、mrna和microrna)输送到内皮细胞中的治疗潜力。
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Exosomes Function in Pro- and Anti-Angiogenesis.

Exosomes, a group of small vesicles (30-100 nm), originate when the inward budding of the endosomal membrane forms multivesicular bodies (MVBs). Exosomes are released into the extracellular space when the MVBs fuse with the plasma membrane. Numerous studies have indicated that exosomes play critical roles in mediating cell-to-cell communication. Also, exosomes are believed to possess a powerful capacity in regulating cell survival/death, inflammation and tumor metastasis, depending on the particular array of molecules contained within a particular population of exosomes. This mini-review will summarize dual roles of exosomes derived from different types of cells (i.e. endothelial cells, tumor cells, platelets, bone-marrow stem cells, cardiomyocytes, myocardial progenitor cells and among others) in endothelial cell proliferation, migration and tube-like formation. In particular, this review will focus on the therapeutic potential of exosomes as a natural nano-particle for delivering pro-/anti-angiogenic factors (proteins, mRNAs and microRNAs) into endothelial cells.

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