{"title":"糖基神经酰胺合成酶在肿瘤耐药和骨髓抑制中的新发现。","authors":"Vineet Gupta, Yong-Yu Liu","doi":"10.4172/2167-0501.1000120","DOIUrl":null,"url":null,"abstract":"Diverging from eliminating tumors, many anticancer agents can result in drug resistance and myelosuppression or bone marrow suppression in patients during the course of chemotherapy. Drug resistance and myelosuppression are two major impediments to the success of chemotherapy. Recent study of Bhinge et al. demonstrates that glucosylceramide synthase (GCS) can determine the opposite effects of doxorubicin on breast cancer stem cells versus bone marrow stem cells in vivo [1,2]. These observations disclose new insights on GCS in stem cells that are basis of drug resistance and myelosuppression.","PeriodicalId":8764,"journal":{"name":"Biochemistry & Pharmacology: Open Access","volume":"2 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2013-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0501.1000120","citationCount":"4","resultStr":"{\"title\":\"New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.\",\"authors\":\"Vineet Gupta, Yong-Yu Liu\",\"doi\":\"10.4172/2167-0501.1000120\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diverging from eliminating tumors, many anticancer agents can result in drug resistance and myelosuppression or bone marrow suppression in patients during the course of chemotherapy. Drug resistance and myelosuppression are two major impediments to the success of chemotherapy. Recent study of Bhinge et al. demonstrates that glucosylceramide synthase (GCS) can determine the opposite effects of doxorubicin on breast cancer stem cells versus bone marrow stem cells in vivo [1,2]. These observations disclose new insights on GCS in stem cells that are basis of drug resistance and myelosuppression.\",\"PeriodicalId\":8764,\"journal\":{\"name\":\"Biochemistry & Pharmacology: Open Access\",\"volume\":\"2 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4172/2167-0501.1000120\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry & Pharmacology: Open Access\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2167-0501.1000120\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry & Pharmacology: Open Access","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2167-0501.1000120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.
Diverging from eliminating tumors, many anticancer agents can result in drug resistance and myelosuppression or bone marrow suppression in patients during the course of chemotherapy. Drug resistance and myelosuppression are two major impediments to the success of chemotherapy. Recent study of Bhinge et al. demonstrates that glucosylceramide synthase (GCS) can determine the opposite effects of doxorubicin on breast cancer stem cells versus bone marrow stem cells in vivo [1,2]. These observations disclose new insights on GCS in stem cells that are basis of drug resistance and myelosuppression.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
