长春新碱在不同大鼠结肠炎模型中引起的感觉和炎性结肠改变

K. V. Viana-Cardoso, M. T. B. Silva, A. A. Peixoto-Junior, L. S. Marinho, N. S. Matias, P. M. G. Soares, A. A. Santos, G. A. C. Brito, F. H. Rola, F. de A. A. Gondim
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引用次数: 2

摘要

临床前和临床研究表明,胃肠道(GI)炎症可以引起远离原始炎症部位的感觉变化。使用三硝基苯磺酸(TNBS)或芥菜油(MO)的结肠炎动物模型产生不同的躯体和内脏感觉改变模式。我们评估了四种剂量150 μg kg - 1静脉注射长春新碱(共600 μg kg - 1)对TNBS或MO诱导的大鼠躯体(热伤害阈)和结肠(形态学)变化的影响。TNBS组和MO组进一步进行长春新碱或生理盐水预处理。TNBS诱导体细胞超敏,而MO诱导体细胞低敏(P <0.05),与生理盐水和乙醇对照组比较。长春新碱本身诱导体细胞超敏反应(P <0.05)。TNBS增强了这种效果,而MO治疗则逆转了这种效果。虽然在tnbs处理的大鼠中,新碱增加了结肠炎面积(结肠重长−1比)和Morris’评分,但在mo处理的大鼠中,它没有改变结肠炎面积,甚至降低了Morris’评分。与生理盐水组(对照组)相比,长春新碱未改变结肠显微模式。然而,这类病变评分较高(P <TNBS和MO诱导结肠炎组,无论是否预处理长春新碱,差异均有统计学意义(0.05)。综上所述,长春新碱对不同实验性结肠炎模型的机体变化具有不同的调节作用。
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Sensory and inflammatory colonic changes induced by vincristine in distinct rat models of colitis

Preclinical and clinical studies show that gastrointestinal (GI) inflammation can evoke sensory changes occasionally far from the original inflammatory site. Animal models of colitis with either trinitrobenzenesulphonic acid (TNBS) or mustard oil (MO) produce distinct patterns of somatic and visceral sensory changes. We evaluated the effects of four doses of i.v. vincristine 150 μg kg−1 (total of 600 μg kg−1) treatment on the somatic (thermal nociceptive threshold) and colonic (morphological) changes induced by TNBS or MO in rats. TNBS and MO groups were further submitted to vincristine or saline pretreatments. TNBS induced somatic hypersensitivity, while MO induced somatic hyposensitivity (P < 0.05) when compared to the saline and ethanol control groups. Vincristine per se induced somatic hypersensitivity (P < 0.05). This effect was enhanced by TNBS and reversed by MO treatments. Although vincristine increased the colitis area (colonic weight length−1 ratio) and the Morris' score in TNBS-treated rats, it did not alter the colitis area and even lowered the Morris' score in MO-treated rats. Compared to the saline (control) group, vincristine did not alter the colonic microscopic pattern. However, such lesions scores are higher (P < 0.05) in colitis groups induced by TNBS and MO, pretreated or not with vincristine. In conclusion, the somatic changes induced by different models of experimental colitis are diverse and modulated differently by vincristine.

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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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