普通遗传变异与总脂肪摄入量对低密度脂蛋白峰值颗粒直径的相互作用:一项全基因组关联研究。

Q Agricultural and Biological Sciences Journal of Nutrigenetics and Nutrigenomics Pub Date : 2015-01-01 Epub Date: 2015-06-20 DOI:10.1159/000431151

Iwona Rudkowska, Louis Pérusse, Claire Bellis, John Blangero, Jean-Pierre Després, Claude Bouchard, Marie-Claude Vohl

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引用次数: 22

摘要

背景/目的:总脂肪摄入量对低密度脂蛋白(LDL)峰值粒径(LDL- ppd)有重要影响，并可能与营养敏感单核苷酸多态性(snp)相互作用。目的是检查魁北克家庭研究(QFS)中是否存在SNP与膳食脂肪摄入相互作用影响LDL-PPD的暗示证据，以便产生假说，在更大规模的研究中进行检验。方法:使用Illumina Human610-Quad BeadChip检测来自全基因组关联研究(GWAS)的SNP，来自3天加权食物记录的总脂肪摄入量，以及SNP ×总脂肪摄入量的相互作用对541名QFS受试者的LDL-PPD的影响。结果:GWAS分析了29个独立SNP与总脂肪摄入相互作用对LDL-PPD的影响，p < 10(-5)，包括以下基因的SNP: ABCG2、CPA3、FNBP1、KCNQ3、NBAS、NCALD、OPRL1、NKAIN2、SH3BGRL2、SOX5和SUSD4。结论:这项观察性研究表明，多个snp与膳食脂肪摄入相互作用，影响LDL-PPD的变化。

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Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study.

Background/aim: Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies.

Methods: SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad BeadChip, total fat intake derived from a 3-day weighted food record, and SNP × total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects.

Results: The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10(-5), including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4.

Conclusions: This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD.

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.