电磁场作用下大鼠糖尿病形成中胎儿素a通路的研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-10-02 Epub Date: 2022-09-08 DOI:10.1080/15368378.2022.2117189
Cemil Sert, Murat Delin, Mehmet Ali Eren, Yusuf Çakmak
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引用次数: 0

摘要

我们生活中科技设备的存在增加了环境电磁场的暴露。因此,特别是癌症和糖尿病正在增加。将大鼠分为3组,每组12只。实验1组(n = 12)每天暴露于0.4 mT 50 Hz极低频磁场6小时,连续5天;实验2组(n = 12)连续暴露10天;对照组(n = 12)不暴露于磁场。应用完成后,在适当条件下采集大鼠血液,在实验室进行测量,并进行组间统计分析。两组间转氨酶、脂质谱及c肽检测结果无显著差异。两组间胰岛素、尿素、肌酐、Na、K、Ca、尿酸参数均无显著差异。然而,在对照组和实验组之间,葡萄糖、HbA1c和Hba1 IFCC值有显著升高(p
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Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to elf magnetic fields.

The presence of technological devices in our lives has increased exposure to environmental electromagnetic fields. As a result of this, especially Cancer and Diabetes are increasing.Rats were divided into 3 groups with 12 rats in each group. The 1st experimental group (n = 12) was exposed to a 50 Hz ELF magnetic field of 0.4 mT for 6 hours a day for 5 days, the 2nd experimental group (n = 12) was exposed for 10 days, and the control group (n = 12) was never exposed to a magnetic field. After completing the applications, blood collection from the rats was performed under appropriate conditions, measurements were made in the laboratory, and statistical analysis was performed between the groups. There was no significant difference between the groups in the results of transaminases and lipid profiles and C-Peptide. There was no significant difference in insulin, urea, creatinine, Na, K, Ca, and uric acid parameters between the groups. However, there was a significant increase in glucose, HbA1c, and Hba1 IFCC values between the control group and the experimental groups (p < .001). There was a significant increase in the level of Fetuin-A between the control group and the experimental groups (p < .05). There was an increase in the Fetuin-A, Glucose, HbA1c, and Hba1c IFCC values in both of the experimental groups compared to the control group. We believe that an increase in these values may cause Type 3 diabetes.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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