心脏TRPV4通道。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-08-01 DOI:10.1016/bs.ctm.2022.06.004
Vivian C Onyali, Timothy L Domeier
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引用次数: 1

摘要

瞬时受体电位香草样蛋白4 (TRPV4)在心脏内的许多细胞类型中表达,但TRPV4在心肌细胞中的表达水平、亚细胞定位和功能相关性尚不清楚。最近的数据表明,TRPV4在心房和心室肌细胞生物学中都起着关键作用,在缺血、心肌梗死、机械应力和炎症等病理情况下,TRPV4的表达水平和通道功能增加。在细胞水平上,TRPV4的过度激活有助于增强Ca2+进入,这使心肌细胞易发生促心律失常的Ca2+过载和电生理异常。在器官水平上,TRPV4活性过高与心脏过度收缩、心脏损伤、室性心律失常和房颤有关。这一手稿章节描述了在生理学和疾病中心肌细胞TRPV4的新兴文献。
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Cardiac TRPV4 channels.

Transient Receptor Potential Vanilloid 4 (TRPV4) is expressed in numerous cell types within the heart, yet the expression levels, subcellular localization, and functional relevance of TRPV4 in cardiac myocytes is under-appreciated. Recent data indicate a critical role of TRPV4 in both atrial and ventricular myocyte biology, with expression levels and channel function increasing following pathological scenarios including ischemia, myocardial infarction, mechanical stress, and inflammation. Excessive activation of TRPV4 at the cellular level contributes to enhanced Ca2+ entry which predisposes the cardiac myocyte to pro-arrhythmic Ca2+ overload and electrophysiological abnormalities. At the organ level, excessive TRPV4 activity associates with cardiac hypercontractility, cardiac damage, ventricular arrhythmia, and atrial fibrillation. This manuscript chapter describes the emerging literature on TRPV4 in cardiac myocytes in physiology and disease.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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