在经过验证的大鼠疼痛模型中减少疼痛:使用仿真®传递系统针对低和超低端的射频频谱。

IF 1.6 4区 生物学 Q3 BIOLOGY Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-10-14 DOI:10.1080/15368378.2022.2131568
Xavier A Figueroa, Lucas Lacambra, B Michael Butters
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引用次数: 0

摘要

仿真治疗公司(EMTx)开发了一种技术,以WAV文件的形式传递时变磁场,通过低频谱的无线电频率(DC到22 kHz)以极低的频率发射,可用于调节疼痛感觉。这些低功率场(~30-70毫高斯交流有效值)通过便携式、轻质可穿戴设备(Voyager)提供。与第三方动物研究机构(ANS Biotech, S.A.)签约,专门研究经过验证的大鼠疼痛模型,独立于作者进行了研究。在这里,我们报告了一组信号在减少内脏疼痛、神经性疼痛和炎症性疼痛的大鼠模型中的疼痛感觉方面具有统计学上显著的作用。此外,去除原始信号中6 kHz以上的频率可以提高未修改信号的镇痛效果。
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Pain reduction in validated rat pain models: radio frequency spectrum targeted at the low and ultra-low ends using the emulate® delivery system.

EMulate Therapeutics, Inc. (EMTx) has developed a technology to deliver time-varying magnetic fields as WAV files, emitted in the extremely low through the low spectrum of radio frequencies (DC to 22 kHz), that can be applied to regulate pain sensation. These low power fields (~30-70 milli-Gauss AC RMS) are delivered via a portable, light-weight wearable device (Voyager). A contract third-party animal research organization (ANS Biotech, S.A.) specializing in validated rat pain models, ran the studies independently of the authors. Here we report that a subset of signals demonstrated a statistically significant effect in reducing the sensation of pain in rat models for visceral pain, neuropathic pain and inflammatory pain. Furthermore, removing frequencies above 6 kHz in the original signals improve the pain reducing effects of the unmodified signal.

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来源期刊
CiteScore
3.60
自引率
11.80%
发文量
33
审稿时长
>12 weeks
期刊介绍: Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.
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