甲型流感病毒三波流行周期的机制分析

Biofizika Pub Date : 2015-05-01
I D Kolesin, E M Zhitkova
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引用次数: 0

摘要

模拟了一种新型血清型病原体引起的三波流行周期。研究了易受影响人群阶层逐步衰退的机制。在模型中引入一组无症状感染者以及抗原活性指数,该指数调节输入到感染患者组的输入流的强度。发病率还受毒力的影响。该模型是根据香港血清型(H3N2)的三波传代观察确定的。仿真结果表明,无症状感染者在提升病原体毒力和补充病态群体方面起主导作用。
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[Analysis of the Mechanism of a Three-Wave Epidemic Influenza A Virus Cvcle].

A three-wave epidemic cycle caused by a new serotype agent is simulated. The mechanism of stepwise recession in a stratum of the susceptible persons is examined. A group of asymptomatic infected individuals as well as an antigen activity index, which regulates the intensity of input streams into the groups of infected patients, are introduced into the model. Morbidity rate is additionally regulated by the virulence. The model is identified according to the observations of the three-wave passage of Hong-Kong serotype (H3N2). On the basis of the simulation results it is shown that a leading role in upgrading the virulence capacity of the agent and in replenishment of the morbid group is assigned to the asymptomatic infected individuals.

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