Eman Mostafa, Bob Storey, Adel Mohammed Farghaly, Hany Abd El-Hai Afify, Afaf Abd El-Raouf Taha, Adrian J Wolstenholme
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Transient effects of levamisole on Brugia malayi microfilariae.
Levamisole is an anthelmintic drug that acts by activating nicotinic acetylcholine receptors at the nematode neuromuscular junction and causing paralysis. We measured the in vitro effects of levamisole on the motility of Brugia malayi microfilariae; after 2 h incubation the apparent IC50 was 2.68 mM. Lower drug concentrations, such as 1 mM, caused an immediate total paralysis that lasted for up to 1 h, but was completely reversed by 2 h of incubation. The 'recovered' parasites were still completely susceptible to application of a second nicotinic agonist, pyrantel.
期刊介绍：
Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include:
Functional analysis of the invertebrate nervous system;
Molecular neuropharmacology and toxicology;
Neurogenetics and genomics;
Functional anatomy;
Neurodevelopment;
Neuronal networks;
Molecular and cellular mechanisms of behavior and behavioural plasticity.
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