麻醉大鼠直接和间接拟交感神经兴奋剂(包括卡西酮)心血管作用的性别差异研究

H. A. Alsufyani, J. R. Docherty
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引用次数: 6

摘要

我们利用雄性和雌性Wistar大鼠,研究了兴奋剂卡西酮(来自阿拉伯茶)(以及亚甲基二氧甲基苯丙胺[MDMA]的比较)和原型间接拟交感神经剂乳胺的直接和间接拟交感神经心血管作用的性别差异。用6-羟多巴胺或载药治疗交感神经切除动物。在雄性和雌性戊巴比妥麻醉大鼠中,所有三种激动剂(0.001-1 mg/kg)均产生明显的心动过速,乳胺产生较大的升压反应,高剂量时产生较小的降压反应,MDMA产生较小的升压反应,卡西酮仅产生较小的升压作用。在交感神经切除的大鼠中,压迫反应,甚至对酪胺的反应,实际上都被消除了,对酪胺的抑制反应也被消除了。在给药的大鼠中,雄性大鼠对酪胺的心动过速明显高于雌性大鼠,而对卡西酮或MDMA的心动过速则没有。这可能表明酪胺引起心动过速的机制不同于兴奋剂卡西酮和MDMA。交感神经切除后,雄性和雌性大鼠对任何药物的心动过速均无差异。因此,对酪胺的心动过速反应存在性别差异,但对广泛使用的娱乐性兴奋剂卡西酮和MDMA的心血管反应没有性别差异。卡西酮和MDMA对雄性和雌性大鼠的心脏刺激作用相似。
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Investigation of gender differences in the cardiovascular actions of direct and indirect sympathomimetic stimulants including cathinone in the anaesthetized rat

  1. We have studied gender differences in the direct and indirect sympathomimetic cardiovascular effects of the stimulant cathinone (from Khat) (and for comparison methylenedioxymethamphetamine [MDMA]) and the archetypal indirect sympathomimetic agent tyramine, employing male and female Wistar rats.
  2. Animals were sympathectomized by treatment with 6-hydroxydopamine or treated with vehicle.
  3. In male and female vehicle-treated pentobarbitone-anaesthetized rats, all three agonists (0.001–1 mg/kg) produced significant tachycardia, tyramine produced large pressor, and in high doses small depressor responses, MDMA produced small pressor responses, and cathinone produced only minor pressor effects.
  4. In sympathectomized rats, pressor responses, even those to tyramine, were virtually abolished, and depressor responses to tyramine were abolished.
  5. In vehicle-treated rats, the tachycardia to tyramine, but not the tachycardia to cathinone or MDMA, was significantly greater in male than female rats. This may suggest that the mechanism of the tachycardia to tyramine differs from those of the stimulants cathinone and MDMA. Following sympathectomy, there were no differences between male and female rats in the tachycardia to any agent.
  6. Hence, there were gender differences in the tachycardia response for tyramine, but no gender differences in the cardiovascular responses to the widely used recreational stimulants cathinone and MDMA. Cardiac stimulant actions of cathinone and MDMA were similar in male and female rats.
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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