大环内酯如何杀死丝线虫幼虫?

Q4 Neuroscience Invertebrate Neuroscience Pub Date : 2016-09-01 Epub Date: 2016-06-09 DOI:10.1007/s10158-016-0190-7
Adrian J Wolstenholme, Mary J Maclean, Ruby Coates, Ciaran J McCoy, Barbara J Reaves
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引用次数: 45

摘要

大环内酯(MLs)是为数不多的用于控制人类丝虫病、盘尾丝虫病和淋巴丝虫病的药物之一,也是唯一用于预防狗和猫心丝虫病的药物。尽管MLs在预防丝虫病方面很重要,但它们对抗这些寄生虫的方式尚不清楚。线虫运动的体外测量显示,在给药后达到的最大血浆浓度与使线虫瘫痪所需的量之间存在很大差异。最近的证据揭示了丝状线虫中ML靶点谷氨酸门控氯通道的可能功能,并支持了治疗后微丝状线虫的快速清除涉及宿主免疫系统的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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How do the macrocyclic lactones kill filarial nematode larvae?

The macrocyclic lactones (MLs) are one of the few classes of drug used in the control of the human filarial infections, onchocerciasis and lymphatic filariasis, and the only one used to prevent heartworm disease in dogs and cats. Despite their importance in preventing filarial diseases, the way in which the MLs work against these parasites is unclear. In vitro measurements of nematode motility have revealed a large discrepancy between the maximum plasma concentrations achieved after drug administration and the amounts required to paralyze worms. Recent evidence has shed new light on the likely functions of the ML target, glutamate-gated chloride channels, in filarial nematodes and supports the hypothesis that the rapid clearance of microfilariae that follows treatment involves the host immune system.

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来源期刊
Invertebrate Neuroscience
Invertebrate Neuroscience NEUROSCIENCES-
自引率
0.00%
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审稿时长
>12 weeks
期刊介绍: Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include: Functional analysis of the invertebrate nervous system; Molecular neuropharmacology and toxicology; Neurogenetics and genomics; Functional anatomy; Neurodevelopment; Neuronal networks; Molecular and cellular mechanisms of behavior and behavioural plasticity.
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