{"title":"聚合酶链反应(PCR)诊断性RAS突变分析","authors":"Ian A. Cree","doi":"10.1016/j.bdq.2016.05.001","DOIUrl":null,"url":null,"abstract":"<div><p><em>RAS</em> mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of <em>RAS</em> mutation status (both <em>KRAS</em> and <em>NRAS</em>), and it is good practice to include <em>BRAF</em>. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of <em>RAS</em> mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.</p></div>","PeriodicalId":38073,"journal":{"name":"Biomolecular Detection and Quantification","volume":"8 ","pages":"Pages 29-32"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bdq.2016.05.001","citationCount":"16","resultStr":"{\"title\":\"Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)\",\"authors\":\"Ian A. Cree\",\"doi\":\"10.1016/j.bdq.2016.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>RAS</em> mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of <em>RAS</em> mutation status (both <em>KRAS</em> and <em>NRAS</em>), and it is good practice to include <em>BRAF</em>. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of <em>RAS</em> mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.</p></div>\",\"PeriodicalId\":38073,\"journal\":{\"name\":\"Biomolecular Detection and Quantification\",\"volume\":\"8 \",\"pages\":\"Pages 29-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bdq.2016.05.001\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomolecular Detection and Quantification\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214753516300080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomolecular Detection and Quantification","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214753516300080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.
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