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{"title":"确定亚甲基四氢叶酸还原酶(MTHFR)基因多态性与基因组DNA甲基化水平之间的关系:一项荟萃分析","authors":"Li Wang, Shaofang Shangguan, Shaoyan Chang, Xin Yu, Zhen Wang, Xiaolin Lu, Lihua Wu, Ting Zhang","doi":"10.1002/bdra.23511","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Background</h3>\n \n <p>The methylenetetrahydrofolate reductase (<i>MTHFR</i>) polymorphism is a risk factor for neural tube defects. C677T and A1298C <i>MTHFR</i> polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A meta-analysis was conducted to assess the association between <i>MTHFR</i> C677T/A1298C genotypes and global genomic methylation.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Eleven studies met the inclusion criteria. Of these, 10 were performed on C677T <i>MTHFR</i> genotypes and 6 were performed on A1298C <i>MTHFR</i> genotypes. Our results did not indicate any correlation between global methylation and <i>MTHFR</i> A1298C, C677T polymorphisms.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results of our study provide evidence to assess the global methylation modification alterations of <i>MTHFR</i> polymorphisms among individuals. However, our data did not found any conceivable proof supporting the hypothesis that common variant of <i>MTHFR</i> A1298C, C677T contributes to methylation modification. Birth Defects Research (Part A) 106:667–674, 2016. © 2016 Wiley Periodicals, Inc.</p>\n </section>\n </div>","PeriodicalId":8983,"journal":{"name":"Birth defects research. Part A, Clinical and molecular teratology","volume":"106 8","pages":"667-674"},"PeriodicalIF":0.0000,"publicationDate":"2016-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bdra.23511","citationCount":"13","resultStr":"{\"title\":\"Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis\",\"authors\":\"Li Wang, Shaofang Shangguan, Shaoyan Chang, Xin Yu, Zhen Wang, Xiaolin Lu, Lihua Wu, Ting Zhang\",\"doi\":\"10.1002/bdra.23511\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The methylenetetrahydrofolate reductase (<i>MTHFR</i>) polymorphism is a risk factor for neural tube defects. C677T and A1298C <i>MTHFR</i> polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A meta-analysis was conducted to assess the association between <i>MTHFR</i> C677T/A1298C genotypes and global genomic methylation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Eleven studies met the inclusion criteria. Of these, 10 were performed on C677T <i>MTHFR</i> genotypes and 6 were performed on A1298C <i>MTHFR</i> genotypes. Our results did not indicate any correlation between global methylation and <i>MTHFR</i> A1298C, C677T polymorphisms.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The results of our study provide evidence to assess the global methylation modification alterations of <i>MTHFR</i> polymorphisms among individuals. However, our data did not found any conceivable proof supporting the hypothesis that common variant of <i>MTHFR</i> A1298C, C677T contributes to methylation modification. Birth Defects Research (Part A) 106:667–674, 2016. © 2016 Wiley Periodicals, Inc.</p>\\n </section>\\n </div>\",\"PeriodicalId\":8983,\"journal\":{\"name\":\"Birth defects research. Part A, Clinical and molecular teratology\",\"volume\":\"106 8\",\"pages\":\"667-674\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/bdra.23511\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Birth defects research. Part A, Clinical and molecular teratology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bdra.23511\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth defects research. Part A, Clinical and molecular teratology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdra.23511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
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