{"title":"“绿色技术”制备的富勒烯C60水分散体的伤口愈合活性","authors":"N.N. Shershakova PhD , S.M. Andreev PhD , A.A. Tomchuk MSc , E.A. Makarova MSc , A.A. Nikonova PhD , E.A. Turetskiy PhD , O.A. Petukhova MSc , O.Y. Kamyshnikov MSc , O.I. Ivankov PhD , O.A. Kyzyma DSc , O.V. Tomchuk PhD , M.V. Avdeev DSc , A.S. Dvornikov DSc, MD , D.A. Kudlay DSc, MD , M.R. Khaitov DSc, MD","doi":"10.1016/j.nano.2022.102619","DOIUrl":null,"url":null,"abstract":"<div><p>In addition to exhibited antioxidant and anti-inflammatory activity, fullerene<span> C60 is a promising wound healing agent<span>. An important stage in the production of fullerene-based ointments is the stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).</span></span></p><p><span><span>As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution </span>nanoclusters have a size of 6 </span>nm and are assembled into agglomerates which reach a size of 150 nm.</p><p>The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.</p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102619"},"PeriodicalIF":4.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Wound healing activity of aqueous dispersion of fullerene C60 produced by “green technology”\",\"authors\":\"N.N. Shershakova PhD , S.M. Andreev PhD , A.A. Tomchuk MSc , E.A. Makarova MSc , A.A. Nikonova PhD , E.A. Turetskiy PhD , O.A. Petukhova MSc , O.Y. Kamyshnikov MSc , O.I. Ivankov PhD , O.A. Kyzyma DSc , O.V. Tomchuk PhD , M.V. Avdeev DSc , A.S. Dvornikov DSc, MD , D.A. Kudlay DSc, MD , M.R. Khaitov DSc, MD\",\"doi\":\"10.1016/j.nano.2022.102619\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In addition to exhibited antioxidant and anti-inflammatory activity, fullerene<span> C60 is a promising wound healing agent<span>. An important stage in the production of fullerene-based ointments is the stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).</span></span></p><p><span><span>As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution </span>nanoclusters have a size of 6 </span>nm and are assembled into agglomerates which reach a size of 150 nm.</p><p>The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.</p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":\"47 \",\"pages\":\"Article 102619\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963422001058\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963422001058","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Wound healing activity of aqueous dispersion of fullerene C60 produced by “green technology”
In addition to exhibited antioxidant and anti-inflammatory activity, fullerene C60 is a promising wound healing agent. An important stage in the production of fullerene-based ointments is the stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).
As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution nanoclusters have a size of 6 nm and are assembled into agglomerates which reach a size of 150 nm.
The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.
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Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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