{"title":"使用装载智能甲氨蝶呤的全氟己烷纳米液滴的超声引导乳腺癌放化疗","authors":"Roghayeh Kamran Samani PhD , Fatemeh Maghsoudinia PhD , Fatemeh Mehradnia PhD , Seyed Hossein Hejazi PhD , Mohsen Saeb PhD , Tayebe Sobhani MSc , Zohreh Farahbakhsh MSc , Masoud A. Mehrgardi PhD , Mohamad Bagher Tavakoli PhD","doi":"10.1016/j.nano.2022.102643","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Chemoradiotherapy with controlled-release </span>nanocarriers<span><span> such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded </span>perfluorohexane<span> NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated </span></span></span><em>in vitro</em> and <em>in vivo</em><span><span>. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound </span>treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with X-ray irradiation. The </span><em>in vitro</em> and <em>in vivo</em><span><span> results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and </span>organ toxicity. Furthermore, the </span><em>in vivo</em><span> results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"48 ","pages":"Article 102643"},"PeriodicalIF":4.7000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets\",\"authors\":\"Roghayeh Kamran Samani PhD , Fatemeh Maghsoudinia PhD , Fatemeh Mehradnia PhD , Seyed Hossein Hejazi PhD , Mohsen Saeb PhD , Tayebe Sobhani MSc , Zohreh Farahbakhsh MSc , Masoud A. Mehrgardi PhD , Mohamad Bagher Tavakoli PhD\",\"doi\":\"10.1016/j.nano.2022.102643\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Chemoradiotherapy with controlled-release </span>nanocarriers<span><span> such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded </span>perfluorohexane<span> NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated </span></span></span><em>in vitro</em> and <em>in vivo</em><span><span>. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound </span>treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with X-ray irradiation. The </span><em>in vitro</em> and <em>in vivo</em><span><span> results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and </span>organ toxicity. Furthermore, the </span><em>in vivo</em><span> results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer.</span></p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":\"48 \",\"pages\":\"Article 102643\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963422001290\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963422001290","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets
Chemoradiotherapy with controlled-release nanocarriers such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded perfluorohexane NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated in vitro and in vivo. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with X-ray irradiation. The in vitro and in vivo results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and organ toxicity. Furthermore, the in vivo results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer.
期刊介绍：
Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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