减肥手术治疗阻塞性睡眠呼吸暂停(OSA)的疗效评价

M. Quintas-Neves , J. Preto , M. Drummond
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引用次数: 30

摘要

在世界范围内,体重和肥胖正在增加,与一些合并症的增加有关,如阻塞性睡眠呼吸暂停(OSA)。减肥手术是一种有效的治疗肥胖的方法,可以改善肥胖相关的合并症。然而,这种治疗与阻塞性睡眠呼吸暂停之间的关系尚不明确。本系统综述旨在评估和描述不同类型的减肥手术对肥胖OSA患者的影响。本综述分析了22篇术前声明呼吸暂停低通气指数(AHI)、呼吸暂停指数(AI)或呼吸障碍指数(RDI)的文章。术后AHI/AI/RDI显著改善,体重指数(BMI)明显下降。此外,几乎每一项研究都表明术后AHI降低至<20/h和/或术后AHI降低50%,少数例外。结合吸收不良和限制性机制的干预措施,如roux-en-Y胃旁路术(RYGB),在解决和改善OSA方面比单纯限制性措施,如腹腔镜可调节胃束带(LAGB)更有效。总之,减肥手术对阻塞性睡眠呼吸暂停有显著影响,在大多数情况下,至少在短期/中期(1-2年)可以缓解或改善。然而,不同的结果必须谨慎解释,因为异质性纳入标准、随访时间、诊断方法和评估变量导致许多潜在的偏差。
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Assessment of bariatric surgery efficacy on Obstructive Sleep Apnea (OSA)

A worldwide rise in weight and obesity is taking place, associated with an increase in several comorbid conditions, such as Obstructive Sleep Apnea (OSA). Bariatric surgery is an effective treatment approach for obesity, with resultant improvement in obesity-related comorbidities. However, the relationship between this type of treatment and OSA is not well established. This systematic review aims to assess and characterize the impact that different types of bariatric surgery have on obese OSA patients. 22 articles with stated preoperative apnea–hypopnea index (AHI), apnea index (AI) or respiratory disturbance index (RDI) were analyzed in this review. A significant improvement in AHI/AI/RDI occurred after surgery, in addition to the foreseeable reduction in body mass index (BMI). Moreover, almost every study stated a postoperative reduction of the AHI to < 20/h and/or a >50% postoperative reduction of AHI, with few exceptions. The interventions with a combined malabsorptive and restrictive mechanism, like roux-en-Y gastric bypass (RYGB), were more efficacious in resolving and improving OSA than purely restrictive ones, like laparoscopic adjustable gastric banding (LAGB).

In conclusion, bariatric surgery has a significant effect on OSA, leading to its resolution or improvement, in the majority of cases, at least in the short/medium term (1–2 years). However, the different results must be interpreted with caution as there are many potential biases resulting from heterogeneous inclusion criteria, duration of follow-up, diagnostic methodology and assessed variables.

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