结直肠癌II期和III期患者的社会人口学和临床病理特征模式:探讨年轻发病的潜在机制

IF 1.8 Q3 ONCOLOGY Journal of Cancer Epidemiology Pub Date : 2017-01-01 Epub Date: 2017-01-23 DOI:10.1155/2017/4024580
Caitlin C Murphy, Hanna K Sanoff, Karyn B Stitzenberg, John A Baron, Jennifer L Lund, Robert S Sandler
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引用次数: 22

摘要

背景和目的。作为了解年轻(年龄< 50岁)人群中结直肠癌(CRC)发病率增加的第一步,我们在以人群为基础的新诊断为II期和III期CRC的患者样本中检查了人口统计学、临床病理、社会经济特征和治疗接受情况。方法。患者样本来自1990/91年、1995年、2000年、2005年和2010年美国国家癌症研究所的护理模式研究(n = 6,862)。通过病历回顾和医师验证获得肿瘤特征和治疗数据。我们比较了年轻(年龄< 50岁)和老年(年龄50-69岁,年龄≥70岁)结直肠癌患者的社会人口学、临床病理特征和治疗模式。结果。与50-69岁(分别为11%和10%)和≥70岁(各为7%)的患者相比,年轻患者更有可能是黑人(13%)和西班牙裔(15%)。年轻白人(41%)和西班牙裔(33%)患者有直肠肿瘤的比例较大,而右结肠肿瘤在年轻黑人患者中最常见(39%)。大多数年轻患者接受了化疗和放疗,尽管接受微卫星不稳定性测试并不理想(27%)。结论。诊断为年轻发病的CRC患者的特征因种族/民族而有很大差异,黑人和西班牙裔患者诊断年龄< 50岁的比例较高。
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Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease.

Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age < 50) populations, we examined demographic, clinicopathologic, and socioeconomic characteristics and treatment receipt in a population-based sample of patients newly diagnosed with stages II and III CRC. Methods. Patients were sampled from the National Cancer Institute's Patterns of Care studies in 1990/91, 1995, 2000, 2005, and 2010 (n = 6, 862). Tumor characteristics and treatment data were obtained through medical record review and physician verification. We compared sociodemographic and clinicopathologic characteristics and treatment patterns of younger (age < 50) and older (age 50-69, age ≥ 70) CRC patients. Results. Younger patients were more likely to be black (13%) and Hispanic (15%) than patients aged 50-69 years (11% and 10%, resp.) and ≥70 years (7% each). A larger proportion of young white (41%) and Hispanic (33%) patients had rectal tumors, whereas tumors in the right colon were the most common in young black patients (39%). The majority of younger patients received chemotherapy and radiation therapy, although receipt of microsatellite instability testing was suboptimal (27%). Conclusion. Characteristics of patients diagnosed with young-onset CRC differ considerably by race/ethnicity, with a higher proportion of black and Hispanic patients diagnosed at the age of < 50 years.

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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
10
审稿时长
20 weeks
期刊介绍: Journal of Cancer Epidemiology is a peer-reviewed, open access journal that publishes original research articles, review articles, case reports, and clinical studies in all areas of cancer epidemiology.
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