阻塞性睡眠呼吸暂停:流行病学和葡萄牙患者概况

A.P. Rodrigues , P. Pinto , B. Nunes , C. Bárbara
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引用次数: 14

摘要

梗阻性睡眠呼吸暂停(OSA)以反复发作的呼吸暂停和低通气为特征,继发于睡眠时上呼吸道塌陷。阻塞性睡眠呼吸暂停常与心血管并发症有关。在葡萄牙,其规模尚不清楚。方法2014年采用葡萄牙全科医生(GP)哨兵网络(Rede m dicos Sentinela)进行横断面研究。参与者GP报告了2013年12月31日在其用户列表中诊断和登记的所有OSA病例。阻塞性睡眠呼吸暂停的发生频率是根据性别和年龄来估计的。OSA患者的特征还包括诊断方法、治疗方法和基础条件。使用调整混杂因素的logistic回归模型计算危险因素与严重OSA之间的相关性(优势比)。结果25岁及以上人群OSA患病率为0.89% (95 CI: 0.80 ~ 1.00%);男性患病率更高,为1.47% (95 CI: 1.30-1.67%), 65 - 74岁人群患病率更高,为2.35%。多数为重度OSA(48.4%)。高血压(75.9%)、肥胖(74.2%)和糖尿病(34.1%)是最常见的合并症。作为男性(OR: 2.6;95 CI: 1.2-5.8)和肥胖(OR: 4.0;95 CI: 1.8-8.6)与严重OSA的风险增加相关。结论OSA的发现频率低于其他国家的估计,这可能与病例定义的差异有关,但也可能与其他作者报道的OSA未被充分诊断有关。
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Obstructive Sleep Apnea: Epidemiology and Portuguese patients profile

Introduction

Obstructive Sleep Apnea (OSA) is characterized by recurrent episodes of apnea and hypopnea, secondary to collapse of the upper airways during sleep. OSA is frequently associated to cardiovascular complications. In Portugal, its magnitude is unknown.

Methods

In 2014 a cross-sectional study was performed using the Portuguese General Practitioner (GP) Sentinel Network (Rede Médicos Sentinela). Participants GP reported all OSA cases diagnosed and registered in their lists of users on the 31 December 2013.

Frequency of OSA has been estimated by sex and age. OSA patients were also characterized by method of diagnosis, treatment, and underlying conditions.

Association between risk factors and severe OSA (odds ratio) was calculated using a logistic regression model adjusting confounding.

Results

Prevalence of OSA on the population aged 25 years or more was 0.89% (95 CI: 0.80–1.00%); it was higher in males 1.47% (95 CI: 1.30–1.67%) and in those aged between 65 and 74 (2.35%). Most had severe OSA (48.4%). Hypertension (75.9%), obesity (74.2%) and diabetes mellitus (34.1%) were the most frequent comorbidities. Being a male (OR: 2.6; 95 CI: 1.2–5.8) and having obesity (OR: 4.0; 95 CI: 1.8–8.6) were associated with an increased risk of severe OSA.

Conclusion

Found frequency of OSA was lower than other countries estimates, which may be explained by differences on case definition but can also suggest underdiagnosis of this condition as reported by other authors.

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