生物钟、饮食和衰老。

Q3 Medicine Nutrition and Healthy Aging Pub Date : 2017-03-31 DOI:10.3233/NHA-160006
Amol Chaudhari, Richa Gupta, Kuldeep Makwana, Roman Kondratov
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引用次数: 36

摘要

饮食和喂养方案影响生物体中的许多生理系统,并可能有助于发展或预防各种病理,包括心血管疾病或代谢综合征。一些饮食范例,如卡路里限制,有许多充分证明的积极代谢作用,以及在不同生物体中延长寿命的潜力。最近,生物钟被提出作为热量限制机制的组成部分。生物钟在行为、生理和新陈代谢方面产生昼夜节律;昼夜节律紊乱与健康状况下降和寿命缩短有关。在这里,我们将重点介绍生物钟与饮食模式之间相互作用的最新进展。我们讨论了如何通过喂养/营养调节生物钟和通过生物钟调节营养信号通路可能有助于卡路里限制对代谢和寿命的有益影响,以及昼夜节律系统是否可以用于未来的医学应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Circadian clocks, diets and aging.

Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as calorie restriction, have many well-documented positive metabolic effects as well as the potential to extend longevity in different organisms. Recently, the circadian clocks were put forward as integral components of the calorie restriction mechanisms. The circadian clocks generate the circadian rhythms in behavior, physiology, and metabolism; circadian disruption is associated with reduced fitness and decreased longevity. Here we focus on recent advances in the interplay between the circadian clocks and dietary paradigms. We discuss how the regulation of the circadian clocks by feeding/nutrients and regulation of nutrient signaling pathways by the clocks may contribute to the beneficial effects of calorie restriction on metabolism and longevity, and whether the circadian system can be engaged for future medical applications.

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来源期刊
Nutrition and Healthy Aging
Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.
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