Alhagi植物药理特性的系统与机理研究进展。

Mohammad Hossein Asghari, Marjan Fallah, Milad Moloudizargari, Fatemeh Mehdikhani, Peyman Sepehrnia, Bigard Moradi
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引用次数: 9

摘要

Alhagi在伊朗(当地称为Khar Shotor)和亚洲其他地区作为一种流行的民间药物而闻名。最近的研究表明,这些物种具有广泛的药理作用。本文对紫菜的植物药理作用和传统用途进行了综述,重点介绍了紫菜的作用机制、有效剂量和给药途径。本文研究的Alhagi种包括:毛竹、骆驼、花椒、伪Alhagi和kirgisorum。为了收录所有最新数据,作者查阅了Web of Science、Embase等多个数据库。研究结果经过严格审查,并根据与主题的相关性进行分类。表格已被用来清楚地表达观点,分歧已通过讨论解决。Alhagi属植物具有重要的生物医学特性,可开发用于临床。假藻原花色素对血液生化因子有显著影响。在Alhagi种中,camelorum和maurorum的抑菌活性最高。大多数观察到的效果都是剂量依赖性的。本文着重指出Alhagi是一种安全、富含低毒性生物活性化合物的植物。由于在摄入特定浓度的假假单胞菌后观察到DNA损伤,因此在使用该植物进行治疗时应注意。需要进一步的研究来证实这些植物的安全性和质量,以供临床医生用作治疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Systematic and Mechanistic Review on the Phytopharmacological Properties of Alhagi Species.

Alhagi species are well known in Iran (locally known as Khar Shotor) and other parts of Asia as a popular folk medicine. Recent research has shown extensive pharmacological effects of these species. This paper is a comprehensive review of the phytopharmacological effects and traditional uses of Alhagi species and their active constituents with special attention to the responsible mechanisms, effective dosages and routes of administration. The Alhagi species studied in this paper include: A. maurorum, A. camelorum, A. persarum, A. pseudoalhagi, and A. kirgisorum. In order to include all the up to date data, the authors went through several databases including the Web of Science, Embase, etc. The findings were critically reviewed and sorted on the basis of relevance to the topic. Tables have been used to clearly present the ideas and discrepancies were settled through discussion. Alhagi species have significant biomedical properties which can be exploited in clinical use. Proantocyanidin isolated from A. pseudoalhagi has significant biochemical effects on blood factors. Among Alhagi species, A. camelorum and A. maurorum possess the highest anti-microbial activity. Most of the effects observed with A. maurorum are dose-dependent. This paper indicates with emphasis that Alhagi species are safe and rich sources of biologically active compounds with low toxicity. Since DNA damage has been observed following the ingestion of specific concentrations of A. pseudalhagi, care should be taken during administration of the plant for therapeutic use. Further studies are required to confirm the safety and quality of these plants to be used by clinicians as therapeutic agents.

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