循环白细胞整体DNA甲基化与乳腺癌危险因素的关系

IF 1.8 Q3 ONCOLOGY Journal of Cancer Epidemiology Pub Date : 2017-01-01 Epub Date: 2017-04-06 DOI:10.1155/2017/2705860
Nayha Chopra-Tandon, Haotian Wu, Kathleen F Arcaro, Susan R Sturgeon
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引用次数: 11

摘要

目前还不清楚白细胞DNA整体甲基化是否与乳腺癌风险有关。在这篇综述中,我们研究了多种乳腺癌危险因素与全球DNA甲基化的三个标记之间的关系:LINE-1, 5-mdC和Alu。截至2016年4月1日,使用Pubmed进行文献检索,结合相关结果,如“白细胞甲基化”、“血液甲基化”、“血液LINE-1甲基化”,以及已知和疑似乳腺癌危险因素的综合列表。总的来说,文献中的绝大多数报告都集中在LINE-1上。在所有研究中,有相当一致的证据表明,男性白细胞DNA中LINE-1甲基化水平高于女性。在所有研究中,没有其他人口统计学、生活方式、饮食或健康状况风险因素与LINE-1 DNA甲基化一致相关。除了性别之外,几乎没有证据表明我们所研究的乳腺癌风险因素与另外两个DNA甲基化标记(5-mdC和Alu)中的任何一个有关。观察到的整体白细胞DNA甲基化与已知乳腺癌危险因素之间缺乏关联的一个可能含义是,整体白细胞DNA甲基化与乳腺癌之间的关联,如果存在的话,是由于疾病效应。
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Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors.

It is not yet clear whether white blood cell DNA global methylation is associated with breast cancer risk. In this review we examine the relationships between multiple breast cancer risk factors and three markers of global DNA methylation: LINE-1, 5-mdC, and Alu. A literature search was conducted using Pubmed up to April 1, 2016, using combinations of relevant outcomes such as "WBC methylation," "blood methylation," "blood LINE-1 methylation," and a comprehensive list of known and suspected breast cancer risk factors. Overall, the vast majority of reports in the literature have focused on LINE-1. There was reasonably consistent evidence across the studies examined that males have higher levels of LINE-1 methylation in WBC DNA than females. None of the other demographic, lifestyle, dietary, or health condition risk factors were consistently associated with LINE-1 DNA methylation across studies. With the possible exception of sex, there was also little evidence that the wide range of breast cancer risk factors we examined were associated with either of the other two global DNA methylation markers: 5-mdC and Alu. One possible implication of the observed lack of association between global WBC DNA methylation and known breast cancer risk factors is that the association between global WBC DNA methylation and breast cancer, if it exists, is due to a disease effect.

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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
10
审稿时长
20 weeks
期刊介绍: Journal of Cancer Epidemiology is a peer-reviewed, open access journal that publishes original research articles, review articles, case reports, and clinical studies in all areas of cancer epidemiology.
期刊最新文献
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