通过多学科建议使严重肥胖者体重减轻≥5%的基因预测因子

Q Agricultural and Biological Sciences Journal of Nutrigenetics and Nutrigenomics Pub Date : 2017-01-01 Epub Date: 2017-06-03 DOI:10.1159/000469662

Erik E J G Aller, Edwin C M Mariman, Freek G Bouwman, Marleen A van Baak

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引用次数: 9

摘要

背景：减肥成功与否取决于遗传因素：减肥成功与否取决于遗传因素，而遗传因素可能因治疗策略而异：从一个涉及饮食建议、心理咨询和增加体育锻炼的多学科肥胖症治疗项目中招募了 587 名受试者（68% 为女性；46.1 ± 12.4 岁；BMI 39.9 ± 6.3）。在基线期，受试者被抽取血液样本进行 DNA 分离。对 25 个候选基因中的 30 个多态性进行了基因型测定。分别在治疗 3 个月（短期）和 12 个月（长期）后评估基因型与体重下降之间的关系。体重减轻分为≥5%或结果：PLIN1的G/G基因型（rs2289487）和PLIN1的G/G基因型（rs2304795）、PLIN1的T/T基因型（rs1052700）和MMP2的C/C基因型预测前3个月体重下降≥5%。PPARγ (rs1801282)的C/G-G/G基因型和TIMP4 (rs3755724)的T/C基因型预测12个月后体重下降≥5%。PPARγ（rs1801282）C/G-G/G和TIMP4（rs3755724）T/C组合的受试者体重下降幅度更大：结论：与脂肪储存调节和脂肪细胞结构适应相关的基因多态性是减肥成功的预测因素，不同基因与短期和长期减肥成功相关。

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Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.

Background: Weight loss success is determined by genetic factors, which may differ according to treatment strategy.

Methods: From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association between genotypes and weight loss was assessed after 3 months (short-term) and after 12 months of treatment (long-term). Weight loss was categorized as ≥5% or <5% of initial weight.

Results: The G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T genotype of PLIN1 (rs1052700), and the C/C genotype of MMP2 predicted ≥5% weight loss in the first 3 months. The C/G-G/G genotype of PPARγ (rs1801282) and the T/C genotype of TIMP4 (rs3755724) predicted ≥5% weight loss after 12 months. Subjects with the combination of PPARγ (rs1801282) C/G-G/G and TIMP4 (rs3755724) T/C lost even more weight.

Conclusion: Polymorphisms in genes related to regulation of fat storage and structural adaptation of the adipocytes are predictors for weight loss success with different genes being relevant for short-term and long-term weight loss success.

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.