加纳中部甲状腺疾病:20年碘化的影响。

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2017-01-01 Epub Date: 2017-07-04 DOI:10.1155/2017/7843972
Osei Sarfo-Kantanka, Ishmael Kyei, Fred Stephen Sarfo, Eunice Oparebea Ansah
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引用次数: 19

摘要

背景:加纳于1996年开始强制食盐加碘。本研究比较了碘化前后甲状腺疾病的患病率。方法:对1982 - 2014年加纳中部地区甲状腺病例进行回顾性研究。为了证明碘化与甲状腺功能亢进和自身免疫之间的联系,我们比较了碘化计划前后甲状腺功能亢进和自身免疫性甲状腺疾病的患病率。结果:共记录10484例,其中女性7548例,男性2936例。甲状腺病例发生率为343/10万。无毒结节性甲状腺肿(25.7%)和毒性结节性甲状腺肿(22.5%)是第二常见的甲状腺疾病。1996年后甲状腺功能亢进的患病率明显高于碘化前的患病率(40.0%对21.1%,p < 0.001)。碘化后记录的自身免疫性疾病患病率显著高于碘化计划开始前(22.3%对9.6%,p < 0.001)。结论:这项研究揭示了几十年来加纳中部甲状腺入院人数的显著增加。本研究显示了碘强化与碘诱导的甲状腺功能亢进以及碘强化与自身免疫性甲状腺炎之间的联系。
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Thyroid Disorders in Central Ghana: The Influence of 20 Years of Iodization.

Background: Ghana began mandatory iodization of salt in 1996. This study compares the prevalence of thyroid disorders before and after the introduction of iodization.

Methods: This is a retrospective study of thyroid cases from the middle belt of Ghana between 1982 and 2014. To demonstrate a link between iodization and hyperthyroidism and autoimmunity, we compared the prevalence of hyperthyroidism and autoimmune thyroid disorders before and after the iodization programme.

Results: A total of 10,484 (7548 females, 2936 males) cases were recorded. The rate of thyroid cases seen was 343/100,000. Nontoxic nodular goiters (25.7%) and toxic nodular goiters (22.5%) represented the second commonest thyroid disorders recorded. The prevalence of hyperthyroid disorders seen after 1996 was significantly higher than the prevalence seen before the iodization (40.0 versus 21.1%, p < 0.001). The prevalence of autoimmune disorders recorded after iodization was significantly higher than that before the iodization programme started (22.3% versus 9.6%, p < 0.001).

Conclusions: This study has revealed a significant increase in thyroid admissions in Central Ghana over the decades. A connection between iodine fortification and iodine-induced hyperthyroidism and between iodine fortification and autoimmune thyroiditis has been shown in this study.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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