María Pérez-Alonso, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, Eladio A Velasco, Lidia Linares, Luis Cuellar, José-Manuel Olmos, Daniel De Luis, Antonio Dueñas-Laita, José-Luis Pérez-Castrillón
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Three SNPs - rs2231142 (ABCG2), rs358231 (cytosolic β-glucosidase [CBG]), and rs2273697 (ABCC2) - were determined.</p><p><strong>Results: </strong>We included 102 women. The effects on bone remodeling were similar: rises in vitamin D were significantly associated with reductions in PTH, CTX, and P1NP. Pharmacogenomic analysis of the genotypes showed that, in AT heterozygotes of the CBG1368T>A polymorphism, CTX and P1NP were not reduced.</p><p><strong>Conclusion: </strong>Genistein added to calcium and vitamin D supplementation had no additional effect. 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引用次数: 8
摘要
目的:本研究的目的是确定补充维生素D和染料木黄酮是否对维生素D和骨标志物水平有有益的影响，以及这种影响是否由调节异黄酮代谢的基因介导。材料和方法:我们对绝经后妇女进行了一项前瞻性研究，随机分为补钙和维生素D组或补钙、维生素D和染料木黄酮组。电化学发光法测定维生素D、甲状旁腺激素(PTH)、交联c -末端肽(CTX)、前胶原1 n -末端(P1NP)含量。检测到rs2231142 (ABCG2)、rs358231(胞浆β-葡萄糖苷酶[CBG])和rs2273697 (ABCC2)三个snp。结果:我们纳入了102名女性。对骨重塑的影响是相似的:维生素D的增加与PTH、CTX和P1NP的降低显著相关。基因型药物基因组学分析显示，CBG1368T>A多态性AT杂合子的CTX和P1NP均未降低。结论:染料木素在钙和维生素D补充剂中添加无额外作用。补充CBG1368T>A多态性的单个AT杂合子对骨重塑标志物没有影响。
The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism.
Aims: The objective of this study was to determine whether vitamin D and genistein supplementation had an additive beneficial effect on levels of vitamin D and bone markers and whether this effect was mediated by genes regulating isoflavone metabolism.
Materials and methods: We carried out a prospective study in postmenopausal women randomized to calcium and vitamin D supplementation or calcium, vitamin D, and genistein supplementation. Vitamin D, parathyroid hormone (PTH), cross-linked C-telopeptide (CTX), and procollagen 1 N-terminal (P1NP) were determined by electrochemiluminescence. Three SNPs - rs2231142 (ABCG2), rs358231 (cytosolic β-glucosidase [CBG]), and rs2273697 (ABCC2) - were determined.
Results: We included 102 women. The effects on bone remodeling were similar: rises in vitamin D were significantly associated with reductions in PTH, CTX, and P1NP. Pharmacogenomic analysis of the genotypes showed that, in AT heterozygotes of the CBG1368T>A polymorphism, CTX and P1NP were not reduced.
Conclusion: Genistein added to calcium and vitamin D supplementation had no additional effect. The supplementation of individual AT heterozygotes of the CBG1368T>A polymorphism had no effect on markers of bone remodeling.
期刊介绍：
The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.
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