尼古丁和红茶对心率变异性的组合影响:有益还是有害?

Autonomic and Autacoid Pharmacology Pub Date : 2017-08-17 DOI:10.1111/aap.12059

S. Joukar, M. Sheibani

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引用次数: 2

摘要

尼古丁对心率变异性(HRV)的影响存在争议。自主神经系统是心律的主要调节者，心率变异性是评价自主神经系统对心脏作用的合适指标。在本研究中，研究了尼古丁和红茶对大鼠交感迷走神经平衡和心率变异性的联合作用。将雄性Wistar大鼠随机分为对照组、茶组(2.5 g/ 100cc，每日)、烟碱组(2 mg/kg/d)和茶加烟碱组，治疗28 d，第29 d记录其心电图(铅ⅱ)。茶组、烟碱组和茶加烟碱组大鼠高频功率(HF)均值显著高于对照组(P <.05)，尼古丁组和茶+尼古丁组的低频功率/高频功率(LF/HF)比显著低于对照组(P <. 05)。各组间LF值无显著差异。与对照组相比，茶组、尼古丁组和茶+尼古丁组的正常RR区间标准差均值(SDNN)和连续RR区间均方根差(RMSSD)的平方根均显著增加(P <(0.05)总体而言，4周的红茶、尼古丁或它们与本研究中使用的剂量组合可以增加大鼠的心率变异性，改善交感神经-迷走神经平衡。

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Combinatorial effect of nicotine and black tea on heart rate variability: Useful or harmful?

The effect of nicotine on heart rate variability (HRV) is controversial. Autonomic nervous system is the main regulator of heart rhythm, and heart rate variability is an appropriate index to assessment of the effects of the autonomic system on heart.
In this study, the combination effect of nicotine and black tea consumption on sympatho-vagal balance and heart rate variability was investigated in rats.
Male Wistar rats were randomized into four groups as control, tea (2.5 g/100 cc, daily), nicotine (2 mg/kg/d) and tea plus nicotine groups which treated for 28 days, and in the 29th day, their electrocardiograms (lead II) were recorded.
The mean of high-frequency power (HF) in tea, nicotine and tea plus nicotine groups was significantly more than control group (P < .05), and low-frequency power/high-frequency power (LF/HF) ratio in the nicotine and tea + nicotine groups was significantly less than control group (P < .05). LF values did not differ significantly among groups. Mean of standard deviation of normal RR intervals (SDNN) and square root of the mean squared differences of successive RR intervals (RMSSD) increased significantly in tea, nicotine and tea + nicotine groups in comparison with control group (P < .05)
Overall, 4-week administration of black tea, nicotine or their combination with dosages used in this study can increase the heart rate variability and improve the sympatho-vagal balance in rat.

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