住院双重诊断治疗对酒精滥用的影响。

Stephen J Schoenthaler, Kenneth Blum, Lyle Fried, Marlene Oscar-Berman, John Giordano, Edward J Modestino, Rajendra Badgaiyan
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引用次数: 41

摘要

这项双重诊断(DD)项目的多中心研究涉及804名同时出现酒精和精神健康障碍的住院患者。在入院时以及出院后1个月、6个月和12个月进行成瘾严重程度指数评估。重复测量分析显示,每个月的中毒率在第6个月至第12个月之间稳定,68%仍处于缓解状态,比基线平均减少88% (F = 519, p < 0.005)。每周复发患者与未复发患者的住院率比较有显著差异(优势比11.3:1;95% ci, 5.5 ~ 23.2)。8个ANCOVAs使用出院后每月平均中毒天数作为结果变量,每月入院前中毒天数作为协变量,8个与复发相关的变量(如抑郁症)作为因素。入院时有这些因素的患者出院后的中毒率并不明显高于没有这些因素的患者。这表明,这些DD项目成功地整合了两种疾病的治疗,并解释了它们的有效性。在第1个月、第6个月和第12个月,共发生的DSM IV情绪障碍,如焦虑和抑郁,以及涉及阿片类药物或可卡因的药物滥用,下降了66%到95%。
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The effects of residential dual diagnosis treatment on alcohol abuse.

This multi-center study of dual diagnosis (DD) programs involved 804 residential patients with co-occurring alcohol and mental health disorders. The Addiction Severity Index was administered at admission and at one, six, and 12 months after discharge. Repeated measures analysis showed the intoxication rate per month stabilized between months six and 12 with 68% still in remission and an 88% mean reduction from baseline (F = 519, p < .005). A comparison between patients with and without weekly relapse produced significant differences in hospitalization (odds ratio 11.3:1; 95% C.I., 5.5 to 23.2). Eight ANCOVAs used mean intoxication days per month after discharge as the outcome variable, pre-admission intoxication days per month as a covariate, and eight variables associated with relapse (e.g. depression) as factors. Patients with these factors at admission did not have significantly higher intoxication rates after discharge than patients without them. This suggests that these DD programs successfully integrated treatment of both disorders and explained their effectiveness. Co-occurring DSM IV mood disorders such as anxiety and depression as well as drug abuse involving opioids or cocaine fell between 66 and 95% at months one, six, and twelve.

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