{"title":"中性粒细胞减少症患者脓毒症的治疗。","authors":"V Zatezalo, N J Gredelj Šimec","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Febrile neutropenia is a common and potentially fatal complication of intense cytotoxic therapy, which makes it the main cause\nof non-relapse mortality in patients with hematologic malignancies. Some of the patients are at risk of specific infections due to\nunderlying disease of previous treatment regimens. Considering that most febrile neutropenic patients can be diagnosed with\nsepsis, diagnosis and treatment should be treated as septic. It is important to recognize patients at high risk since the incidence\nof sepsis in neutropenic patients can be significantly reduced using antimicrobial prophylaxis and granulocyte growth factors.\nOnce sepsis occurs, prompt treatment according to guidelines, individualized based on the specific problems of each patient,\nand microbiological situation can significantly reduce mortality and morbidity.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[TREATMENT OF SEPSIS IN NEUTROPENIC PATIENTS].\",\"authors\":\"V Zatezalo, N J Gredelj Šimec\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Febrile neutropenia is a common and potentially fatal complication of intense cytotoxic therapy, which makes it the main cause\\nof non-relapse mortality in patients with hematologic malignancies. Some of the patients are at risk of specific infections due to\\nunderlying disease of previous treatment regimens. Considering that most febrile neutropenic patients can be diagnosed with\\nsepsis, diagnosis and treatment should be treated as septic. It is important to recognize patients at high risk since the incidence\\nof sepsis in neutropenic patients can be significantly reduced using antimicrobial prophylaxis and granulocyte growth factors.\\nOnce sepsis occurs, prompt treatment according to guidelines, individualized based on the specific problems of each patient,\\nand microbiological situation can significantly reduce mortality and morbidity.</p>\",\"PeriodicalId\":35756,\"journal\":{\"name\":\"Acta Medica Croatica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Medica Croatica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Croatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Febrile neutropenia is a common and potentially fatal complication of intense cytotoxic therapy, which makes it the main cause
of non-relapse mortality in patients with hematologic malignancies. Some of the patients are at risk of specific infections due to
underlying disease of previous treatment regimens. Considering that most febrile neutropenic patients can be diagnosed with
sepsis, diagnosis and treatment should be treated as septic. It is important to recognize patients at high risk since the incidence
of sepsis in neutropenic patients can be significantly reduced using antimicrobial prophylaxis and granulocyte growth factors.
Once sepsis occurs, prompt treatment according to guidelines, individualized based on the specific problems of each patient,
and microbiological situation can significantly reduce mortality and morbidity.
期刊介绍:
ACTA MEDICA CROATICA publishes original contributions to medical sciences, that have not been previously published. All manuscripts should be written in English.