M Bogdanović Dvorščak, T Lupis, M Adanić, J Pavičić Šarić
{"title":"[脓毒症的急性呼吸窘迫综合征和其他呼吸系统疾病]。","authors":"M Bogdanović Dvorščak, T Lupis, M Adanić, J Pavičić Šarić","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Acute respiratory distress syndrome (ARDS) develops in patients with predisposing conditions that induce systemic inflammatory\nresponse such as sepsis, pneumonia, acute pancreatitis, major trauma, or multiple transfusions. Sepsis is the most common cause\nof ARDS. Sepsis-related ARDS patients have significantly lower PaO2 /FiO2 ratios than patients with non-sepsis-related ARDS.\nFurthermore, their recovery from lung injury is prolonged, weaning from mechanical ventilation less successful, and extubation\nrate slower. Clinical outcomes in patients with sepsis-related ARDS are also worse, associated with significantly higher 28-day\nand 60-day mortality rates (31.1% vs. 16.3% and 38.2% vs. 22.6%, respectively). It is extremely important to optimally adjust\nventilator setting to current condition of lungs, while providing all other therapeutic measures in the treatment of sepsis, severe\nsepsis and septic shock. The pool of data on treatment possibilities for patients with ARDS grows every year, with specifically\ndesigned mechanical ventilation strategies. Ventilator modes and adequate positive end-expiratory pressure (PEEP) settings play\na major role in these strategies. However, how can we best apply these experimental and clinical data to everyday clinical practice?\nThis article emphasizes protective ventilation as a measure that is proven to reduce mortality in this group of patients, when\nsystematically and consistently applied.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[ACUTE RESPIRATORY DISTRESS SYNDROME AND OTHER RESPIRATORY DISORDERS IN SEPSIS].\",\"authors\":\"M Bogdanović Dvorščak, T Lupis, M Adanić, J Pavičić Šarić\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute respiratory distress syndrome (ARDS) develops in patients with predisposing conditions that induce systemic inflammatory\\nresponse such as sepsis, pneumonia, acute pancreatitis, major trauma, or multiple transfusions. Sepsis is the most common cause\\nof ARDS. Sepsis-related ARDS patients have significantly lower PaO2 /FiO2 ratios than patients with non-sepsis-related ARDS.\\nFurthermore, their recovery from lung injury is prolonged, weaning from mechanical ventilation less successful, and extubation\\nrate slower. Clinical outcomes in patients with sepsis-related ARDS are also worse, associated with significantly higher 28-day\\nand 60-day mortality rates (31.1% vs. 16.3% and 38.2% vs. 22.6%, respectively). It is extremely important to optimally adjust\\nventilator setting to current condition of lungs, while providing all other therapeutic measures in the treatment of sepsis, severe\\nsepsis and septic shock. The pool of data on treatment possibilities for patients with ARDS grows every year, with specifically\\ndesigned mechanical ventilation strategies. Ventilator modes and adequate positive end-expiratory pressure (PEEP) settings play\\na major role in these strategies. However, how can we best apply these experimental and clinical data to everyday clinical practice?\\nThis article emphasizes protective ventilation as a measure that is proven to reduce mortality in this group of patients, when\\nsystematically and consistently applied.</p>\",\"PeriodicalId\":35756,\"journal\":{\"name\":\"Acta Medica Croatica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Medica Croatica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Croatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[ACUTE RESPIRATORY DISTRESS SYNDROME AND OTHER RESPIRATORY DISORDERS IN SEPSIS].
Acute respiratory distress syndrome (ARDS) develops in patients with predisposing conditions that induce systemic inflammatory
response such as sepsis, pneumonia, acute pancreatitis, major trauma, or multiple transfusions. Sepsis is the most common cause
of ARDS. Sepsis-related ARDS patients have significantly lower PaO2 /FiO2 ratios than patients with non-sepsis-related ARDS.
Furthermore, their recovery from lung injury is prolonged, weaning from mechanical ventilation less successful, and extubation
rate slower. Clinical outcomes in patients with sepsis-related ARDS are also worse, associated with significantly higher 28-day
and 60-day mortality rates (31.1% vs. 16.3% and 38.2% vs. 22.6%, respectively). It is extremely important to optimally adjust
ventilator setting to current condition of lungs, while providing all other therapeutic measures in the treatment of sepsis, severe
sepsis and septic shock. The pool of data on treatment possibilities for patients with ARDS grows every year, with specifically
designed mechanical ventilation strategies. Ventilator modes and adequate positive end-expiratory pressure (PEEP) settings play
a major role in these strategies. However, how can we best apply these experimental and clinical data to everyday clinical practice?
This article emphasizes protective ventilation as a measure that is proven to reduce mortality in this group of patients, when
systematically and consistently applied.
期刊介绍:
ACTA MEDICA CROATICA publishes original contributions to medical sciences, that have not been previously published. All manuscripts should be written in English.