用于下一代无线胶囊内窥镜的紧凑型靶向给药机制。

IF 1.6 Q3 ROBOTICS Journal of Micro-Bio Robotics Pub Date : 2016-01-01 Epub Date: 2016-05-13 DOI:10.1007/s12213-016-0088-9

Stephen P Woods, Timothy G Constandinou

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摘要

本文报告了一种新型药物释放和递送机制，它是下一代无线胶囊内窥镜（WCE）的一部分，用于靶向药物递送。该子系统的体积仅为 17.9 立方毫米，可将 1 毫升有效载荷输送到小肠道的目标部位。报告对释放和输送药物的方法进行了深入分析，并介绍了一系列验证药物输送系统的实验。实验结果表明，用不锈钢制造的可变间距锥形压缩弹簧在完全压缩时可提供 0.59 牛顿的力，而这一力道足以输送机载药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A compact targeted drug delivery mechanism for a next generation wireless capsule endoscope.

This paper reports a novel medication release and delivery mechanism as part of a next generation wireless capsule endoscope (WCE) for targeted drug delivery. This subsystem occupies a volume of only 17.9mm³ for the purpose of delivering a 1 ml payload to a target site of interest in the small intestinal tract. An in-depth analysis of the method employed to release and deliver the medication is described and a series of experiments is presented which validates the drug delivery system. The results show that a variable pitch conical compression spring manufactured from stainless steel can deliver 0.59 N when it is fully compressed and that this would be sufficient force to deliver the onboard medication.

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来源期刊

Journal of Micro-Bio Robotics ROBOTICS-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The Journal of Micro-Bio Robotics (JMBR) focuses on small-scale robotic systems, which could be also biologically inspired, integrated with biological entities, or used for biological or biomedical applications. The journal aims to report the significant progresses in such new research topics. JMBR is devoted to the theory, experiments, and applications of micro/nano- and biotechnologies and small-scale robotics. It promotes both theoretical and practical engineering research based on the analysis and synthesis from the micro/nano level to the biological level of robotics. JMBR includes survey and research articles. Authors are invited to submit their original research articles or review articles for publication consideration. All submissions will be peer reviewed subject to the standards of the journal. Manuscripts based on previously published conference papers must be extended substantially.