Pub Date : 2024-01-01Epub Date: 2024-08-03DOI: 10.1007/s12213-024-00175-y
Subrahmanyam Cherukumilli, Fatma Ceren Kirmizitas, David P Rivas, Max Sokolich, M Cagatay Karakan, Alice E White, Sambeeta Das
The field of microrobotics has emerged as a promising area of research with significant applications in biomedicine, both in vitro and in vivo, such as targeted cargo delivery, microsurgery, and cellular manipulation. Microrobots actuated with multiple modalities have the potential for greater adaptability, robustness, and capability to perform various tasks. Modular units that can reconfigure into various shapes, create structures that may be difficult to fabricate as one whole unit, and be assembled on-site, could provide more versatility by assembly and disassembly of units on demand. Such multi-modal modular microrobots have the potential to address challenging applications. Here, we present a biocompatible cylindrical microrobot with a dome-shaped cavity. The microrobot is actuated by both magnetic and acoustic fields and forms modular microstructures of various shapes. We demonstrate the use of these microrobots for cellular manipulation by creating patterns on a surface.
Supplementary information: The online version contains supplementary material available at 10.1007/s12213-024-00175-y.
{"title":"Programmable acoustic modular microrobots.","authors":"Subrahmanyam Cherukumilli, Fatma Ceren Kirmizitas, David P Rivas, Max Sokolich, M Cagatay Karakan, Alice E White, Sambeeta Das","doi":"10.1007/s12213-024-00175-y","DOIUrl":"10.1007/s12213-024-00175-y","url":null,"abstract":"<p><p>The field of microrobotics has emerged as a promising area of research with significant applications in biomedicine, both in vitro and in vivo, such as targeted cargo delivery, microsurgery, and cellular manipulation. Microrobots actuated with multiple modalities have the potential for greater adaptability, robustness, and capability to perform various tasks. Modular units that can reconfigure into various shapes, create structures that may be difficult to fabricate as one whole unit, and be assembled on-site, could provide more versatility by assembly and disassembly of units on demand. Such multi-modal modular microrobots have the potential to address challenging applications. Here, we present a biocompatible cylindrical microrobot with a dome-shaped cavity. The microrobot is actuated by both magnetic and acoustic fields and forms modular microstructures of various shapes. We demonstrate the use of these microrobots for cellular manipulation by creating patterns on a surface.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12213-024-00175-y.</p>","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"20 2","pages":"11"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.1007/s12213-023-00152-x
G. Adam, G. Ulliac, C. Clévy, D. Cappelleri
{"title":"3D printed vision-based micro-force sensors for microrobotic applications","authors":"G. Adam, G. Ulliac, C. Clévy, D. Cappelleri","doi":"10.1007/s12213-023-00152-x","DOIUrl":"https://doi.org/10.1007/s12213-023-00152-x","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46757485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.1007/s12213-023-00154-9
G. Géron, C. Prelle, H. Al Hajjar, J. Terrien, M. Khan
{"title":"Characterization of a magnetic localization method based on Hall effect sensor array for microrobot position tracking","authors":"G. Géron, C. Prelle, H. Al Hajjar, J. Terrien, M. Khan","doi":"10.1007/s12213-023-00154-9","DOIUrl":"https://doi.org/10.1007/s12213-023-00154-9","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-04-22DOI: 10.1007/s12213-023-00156-7
Azaam Aziz, Richard Nauber, Ana Sánchez Iglesias, Min Tang, Libo Ma, Luis M Liz-Marzán, Oliver G Schmidt, Mariana Medina-Sánchez
Micro-and nanorobots have the potential to perform non-invasive drug delivery, sensing, and surgery in living organisms, with the aid of diverse medical imaging techniques. To perform such actions, microrobots require high spatiotemporal resolution tracking with real-time closed-loop feedback. To that end, photoacoustic imaging has appeared as a promising technique for imaging microrobots in deep tissue with higher molecular specificity and contrast. Here, we present different strategies to track magnetically-driven micromotors with improved contrast and specificity using dedicated contrast agents (Au nanorods and nanostars). Furthermore, we discuss the possibility of improving the light absorption properties of the employed nanomaterials considering possible light scattering and coupling to the underlying metal-oxide layers on the micromotor's surface. For that, 2D COMSOL simulation and experimental results were correlated, confirming that an increased spacing between the Au-nanostructures and the increase of thickness of the underlying oxide layer lead to enhanced light absorption and preservation of the characteristic absorption peak. These characteristics are important when visualizing the micromotors in a complex in vivo environment, to distinguish them from the light absorption properties of the surrounding natural chromophores.
Supplementary information: The online version contains supplementary material available at 10.1007/s12213-023-00156-7.
{"title":"Nanomaterial-decorated micromotors for enhanced photoacoustic imaging.","authors":"Azaam Aziz, Richard Nauber, Ana Sánchez Iglesias, Min Tang, Libo Ma, Luis M Liz-Marzán, Oliver G Schmidt, Mariana Medina-Sánchez","doi":"10.1007/s12213-023-00156-7","DOIUrl":"10.1007/s12213-023-00156-7","url":null,"abstract":"<p><p>Micro-and nanorobots have the potential to perform non-invasive drug delivery, sensing, and surgery in living organisms, with the aid of diverse medical imaging techniques. To perform such actions, microrobots require high spatiotemporal resolution tracking with real-time closed-loop feedback. To that end, photoacoustic imaging has appeared as a promising technique for imaging microrobots in deep tissue with higher molecular specificity and contrast. Here, we present different strategies to track magnetically-driven micromotors with improved contrast and specificity using dedicated contrast agents (Au nanorods and nanostars). Furthermore, we discuss the possibility of improving the light absorption properties of the employed nanomaterials considering possible light scattering and coupling to the underlying metal-oxide layers on the micromotor's surface. For that, 2D COMSOL simulation and experimental results were correlated, confirming that an increased spacing between the Au-nanostructures and the increase of thickness of the underlying oxide layer lead to enhanced light absorption and preservation of the characteristic absorption peak. These characteristics are important when visualizing the micromotors in a complex in vivo environment, to distinguish them from the light absorption properties of the surrounding natural chromophores.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12213-023-00156-7.</p>","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"1 1","pages":"37-45"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10756870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41724817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28DOI: 10.1007/s12213-022-00151-4
Dharmveer Agarwal, A. D. Thakur, Atul Thakur
{"title":"Magnetic microbot-based micromanipulation of surrogate biological objects in fluidic channels","authors":"Dharmveer Agarwal, A. D. Thakur, Atul Thakur","doi":"10.1007/s12213-022-00151-4","DOIUrl":"https://doi.org/10.1007/s12213-022-00151-4","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46367560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1007/s12213-022-00146-1
K. Sravani, Desala Ramakrishna, P. Chandh, Kuncham Sathvik, K. Rao
{"title":"Design of Micropump with two stacked ring type piezoelectric actuators for drug delivery","authors":"K. Sravani, Desala Ramakrishna, P. Chandh, Kuncham Sathvik, K. Rao","doi":"10.1007/s12213-022-00146-1","DOIUrl":"https://doi.org/10.1007/s12213-022-00146-1","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"17 1","pages":"69 - 78"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52752249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1007/s12213-022-00147-0
A. Bagchi, Amalendu Biswas, Gurdeep Singh, S. Sarkar, P. Mukhopadhyay
{"title":"Finite element analysis of a FSMA microgripper for determination of force experienced by it due to photo induced micro actuation effect","authors":"A. Bagchi, Amalendu Biswas, Gurdeep Singh, S. Sarkar, P. Mukhopadhyay","doi":"10.1007/s12213-022-00147-0","DOIUrl":"https://doi.org/10.1007/s12213-022-00147-0","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"8 1","pages":"79 - 92"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52752281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-07DOI: 10.1007/s12213-022-00148-z
T. Hogg
{"title":"Acoustic power management by swarms of microscopic robots","authors":"T. Hogg","doi":"10.1007/s12213-022-00148-z","DOIUrl":"https://doi.org/10.1007/s12213-022-00148-z","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"17 1","pages":"93 - 102"},"PeriodicalIF":2.3,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45416442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-26DOI: 10.1007/s12213-021-00145-8
Ashkan Ghanbarzadeh-Dagheyan, N. Jalili, M. Ahmadian
{"title":"A holistic survey on mechatronic Systems in Micro/Nano scale with challenges and applications","authors":"Ashkan Ghanbarzadeh-Dagheyan, N. Jalili, M. Ahmadian","doi":"10.1007/s12213-021-00145-8","DOIUrl":"https://doi.org/10.1007/s12213-021-00145-8","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"17 1","pages":"1 - 22"},"PeriodicalIF":2.3,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12213-021-00145-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42572235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-09DOI: 10.1007/s12213-021-00141-y
Joel Miranda Guaderrama, E. Martínez-García
{"title":"Centipede bio-extremity elastic model control","authors":"Joel Miranda Guaderrama, E. Martínez-García","doi":"10.1007/s12213-021-00141-y","DOIUrl":"https://doi.org/10.1007/s12213-021-00141-y","url":null,"abstract":"","PeriodicalId":44493,"journal":{"name":"Journal of Micro-Bio Robotics","volume":"17 1","pages":"35 - 57"},"PeriodicalIF":2.3,"publicationDate":"2021-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12213-021-00141-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49298049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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