{"title":"[慢性肾病患者使用他汀类药物预防心血管疾病]。","authors":"T Zavidić, B Lodeta, Đ Lovrinić","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is one of the leading public health issues due to frequent and serious complications. Once\nthe function of kidneys is disrupted, regardless of etiology, there are numerous factors that can speed up decrease of\nglomerular filtration rate, including hypertension, proteinuria and dyslipidemia. Statins are widely used in primary and\nsecondary prevention of cardiovascular diseases in general population. Clinical advantages of statins in CKD patients\nare not as clear. The aim of this paper is to present lipid status in CKD patients and indications for statin therapy with the\naim to reduce cardiovascular risk in this group of patients. CKD is a well-known independent risk factor in cardiovascular\nevents, but professional associations issuing guidelines differ in the approach to treatment of dyslipidemia. The results\nof some studies indicate that treatment with statins may slow down the rate of kidney function reduction in patients with\nmild to moderate kidney damage, whereas other studies deny this effect. Furthermore, CKD patients have a higher risk\nof side effects, in part due to the reduced kidney excretion, polypharmacy, and numerous other comorbidities. Family\nphysician has the role of providing preventive measures, with focus on appropriate treatment of patients with hypertension\nor diabetes, as the most common cause of CKD, and timely detection of CKD in initial stage.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[USE OF STATINS IN PATIENTS WITH CHRONIC KIDNEY DISEASE TO PREVENT\\nCARDIOVASCULAR DISEASE].\",\"authors\":\"T Zavidić, B Lodeta, Đ Lovrinić\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chronic kidney disease (CKD) is one of the leading public health issues due to frequent and serious complications. Once\\nthe function of kidneys is disrupted, regardless of etiology, there are numerous factors that can speed up decrease of\\nglomerular filtration rate, including hypertension, proteinuria and dyslipidemia. Statins are widely used in primary and\\nsecondary prevention of cardiovascular diseases in general population. Clinical advantages of statins in CKD patients\\nare not as clear. The aim of this paper is to present lipid status in CKD patients and indications for statin therapy with the\\naim to reduce cardiovascular risk in this group of patients. CKD is a well-known independent risk factor in cardiovascular\\nevents, but professional associations issuing guidelines differ in the approach to treatment of dyslipidemia. The results\\nof some studies indicate that treatment with statins may slow down the rate of kidney function reduction in patients with\\nmild to moderate kidney damage, whereas other studies deny this effect. Furthermore, CKD patients have a higher risk\\nof side effects, in part due to the reduced kidney excretion, polypharmacy, and numerous other comorbidities. Family\\nphysician has the role of providing preventive measures, with focus on appropriate treatment of patients with hypertension\\nor diabetes, as the most common cause of CKD, and timely detection of CKD in initial stage.</p>\",\"PeriodicalId\":35756,\"journal\":{\"name\":\"Acta Medica Croatica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Medica Croatica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Croatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[USE OF STATINS IN PATIENTS WITH CHRONIC KIDNEY DISEASE TO PREVENT
CARDIOVASCULAR DISEASE].
Chronic kidney disease (CKD) is one of the leading public health issues due to frequent and serious complications. Once
the function of kidneys is disrupted, regardless of etiology, there are numerous factors that can speed up decrease of
glomerular filtration rate, including hypertension, proteinuria and dyslipidemia. Statins are widely used in primary and
secondary prevention of cardiovascular diseases in general population. Clinical advantages of statins in CKD patients
are not as clear. The aim of this paper is to present lipid status in CKD patients and indications for statin therapy with the
aim to reduce cardiovascular risk in this group of patients. CKD is a well-known independent risk factor in cardiovascular
events, but professional associations issuing guidelines differ in the approach to treatment of dyslipidemia. The results
of some studies indicate that treatment with statins may slow down the rate of kidney function reduction in patients with
mild to moderate kidney damage, whereas other studies deny this effect. Furthermore, CKD patients have a higher risk
of side effects, in part due to the reduced kidney excretion, polypharmacy, and numerous other comorbidities. Family
physician has the role of providing preventive measures, with focus on appropriate treatment of patients with hypertension
or diabetes, as the most common cause of CKD, and timely detection of CKD in initial stage.
期刊介绍:
ACTA MEDICA CROATICA publishes original contributions to medical sciences, that have not been previously published. All manuscripts should be written in English.