妊娠期传统食用金菊果肉可作为间歇性预防疟疾感染的一种方法。

Chibueze Peter Ihekwereme, Frances Kaosiso Okoye, Sandra Chinenye Agu, Angus Nnamdi Oli
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引用次数: 5

摘要

背景:据报道,金菊树皮具有抗疟作用。尼日利亚东南部孕妇食用的紫锥菊果肉也可能具有抗疟疾活性。本研究初步探讨了白玉莲果肉汁和种子的抗疟潜力。方法:采用Peter’s 4天抑菌试验评价其杀菌活性。在白化病小鼠接种白氏疟原虫后,评价了提取物的预防和治疗抗疟疾活性。结果:牙髓提取物口服急性毒性剂量大于5000mg /kg。种子和果肉具有抑制和治疗的双重特性。500 mg/kg和1000 mg/kg种子提取物对早期侵染的抑制作用分别为72.97%和97.30%。500 mg/kg和1000 mg/kg时,果肉汁率分别为72.97%和81.08%。在500 mg/kg剂量下,第7天对种子和果肉的防虫率相同(96.10%)。结论:本研究证实了在化学性质不确定的白莲果果肉和种子中存在抗疟成分。它的民族医学用途在怀孕期间可能很有价值,因为它可能作为疟疾的间歇性预防疗法。
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Traditional Consumption of the Fruit Pulp of Chrysophyllum albidum (Sapotaceae) in Pregnancy may be Serving as an Intermittent Preventive Therapy against Malaria Infection.

Background: The bark of Chrysophyllum albidum is reported to possess antimalarial property. The fruit pulp of C. albidum consumed by pregnant women of south eastern Nigeria may also possess antimalarial activity. The present preliminary study investigated the antimalarial potential of the pulp juice and seed of C. albidum.

Methods: Schizonticidal activity was evaluated using the Peter's 4-day suppressive test. The prophylactic and curative antimalarial activities of the extracts were evaluated in Albino mice inoculated with Plasmodium berghei.

Results: The oral acute toxic dose of the pulp extract is beyond 5000 mg/kg. The seed and pulp possess both suppressive and curative properties. The seed extract suppressed early infection by 72.97% and 97.30%, at 500 and 1000 mg/kg, respectively. The pulp juice recorded 72.97% and 81.08%, at 500 and 1000 mg/kg, respectively. At 500 mg/kg dose, the level of parasite control on Day 7 was the same (96.10%) for both seed and pulp.

Conclusion: This study demonstrates the presence of antimalarial constituents in the chemically uncharacterized samples (fruit pulp and seed) of C. albidum. Its ethnomedicinal use may be valuable in pregnancy where it may possibly serve as an intermittent preventive therapy against malaria.

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