西番莲花标准提取物对帕金森病和阿尔茨海默病的保护作用。

Suvarna P Ingale, Sanjay B Kasture
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引用次数: 16

摘要

背景:氧化应激在阿尔茨海默病和帕金森病等神经退行性疾病的发病机制中起重要作用。黄酮类化合物通过中和所有类型的氧化自由基(包括超氧化物和羟基自由基)来发挥其抗氧化作用。西番莲(Passifloraceae)是阿育吠陀(Ayurveda)中用于治疗各种中枢神经系统疾病的重要植物,是黄酮类化合物的丰富来源。目的:研究牛皮花富黄酮正丁醇提取物(BEPIF)的抗氧化、抗帕金森和增强记忆活性。材料和方法:采用DPPH和过氧化氢清除法测定抗氧化活性。采用氟哌啶醇诱导的猝睡和他克林诱导的空洞咀嚼运动评估抗帕金森活性,采用升高+迷宫和物体识别测试评估记忆增强活性。统计分析:采用方差分析检验和Dunnett检验对结果进行分析。结果:BEPIF在第2天和第9天的升高+迷宫测试中显著降低了转移潜伏期,在物体识别测试中显著提高了辨别指数,提示其具有认知改善作用。BEPIF预处理显示氟哌啶醇诱导的猝倒和他克林诱导的下颌运动显著减少,这提示其抗帕金森活性。在DPPH和H2O2清除实验中,BEPIF表现出明显的自由基清除活性。结论:马齿苋花丁醇提取物具有显著的抗帕金森和增强认知活性,这可能与其抗氧化作用有关。因此,红花可用于治疗痴呆和帕金森病。
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Protective Effect of Standardized Extract of Passiflora incarnata Flower in Parkinson's and Alzheimer's Disease.

Background: Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Flavonoids exert their antioxidant effects by neutralizing all types of oxidizing radicals including the superoxide and hydroxyl radicals. Passiflora incarnata Linn. (Passifloraceae) is an important plant used in Ayurveda for the treatment of various disorders of the CNS and is a rich source of flavonoids.

Aim: In the present study, we investigated the antioxidant, antiparkinsonian, and memory enhancing activity of flavonoid rich n-butanol extract of P. incarnata flowers (BEPIF).

Materials and methods: Antioxidant activity was assessed using DPPH and hydrogen peroxide scavenging assay. The antiparkinsonian activity was evaluated using haloperidol induced catalepsy and tacrine induced vacuous chewing movement and memory enhancing activity was assessed using elevated plus maze and object recognition test.

Statistical analysis: The results were analyzed by Analysis of Variance test followed by Dunnett's test.

Results: Administration of BEPIF decreased transfer latency on day 2 and 9 significantly in elevated plus maze test and showed a significant increase in discrimination index in the object recognition test which is suggestive of its cognitive improvement action. Pretreatment with BEPIF showed a significant reduction in the haloperidol induced catalepsy and the tacrine induced jaw movements which are suggestive of its antiparkinsonian activity. In DPPH and H2O2 scavenging assay, BEPIF exhibited significant free radical scavenging activity.

Conclusions: It can be concluded that the butanolic extract of P. incarnata flowers has significant antiparkinsonian and cognition enhancing activity which may be associated with its antioxidant potential. Thus, P. incarnata flowers may be employed in treatment of dementia and parkinsonism.

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