比较丙泊酚加芬太尼与咪达唑仑加芬太尼在晚期肝病患者诊断内窥镜中的镇静作用的随机对照研究

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY International Journal of Hepatology Pub Date : 2017-01-01 Epub Date: 2017-09-26 DOI:10.1155/2017/8462756
Sameh Abdelkhalik Ahmed, Amal Selim, Nehad Hawash, Ahmed Khaled Tawfik, Mohamed Yousef, Abdelrahman Kobtan, Rehab Badawi, Sally Elnawasany, Reham Abdelkader Elkhouly, Amr Shaaban Hanafy, Fatma H Rizk, Loai Mansour, Sherief Abd-Elsalam
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引用次数: 7

摘要

目的:我们旨在研究异丙酚加芬太尼与咪达唑仑加芬太尼作为胃肠道内窥镜检查的晚期肝病患者的镇静剂的安全性和有效性。方法:选取100例肝硬化上内镜患者,平均分为咪达唑仑加芬太尼组和异丙酚加芬太尼组。所有患者均接受病史记录、镇静水平评估、内镜评估和血流动力学参数,包括血氧饱和度、心率、平均动脉压、副作用发生率(心动过缓、低血压、缺氧、恶心呕吐、咳嗽、寒战或复视)、完全恢复所需时间和出院所需时间。结果:两组患者在年龄、性别、体重、Child-Pugh分级评分、内镜干预类型及持续时间、完全恢复时间、出院时间等方面差异均无统计学意义。两组的并发症发生率相似,但异丙酚和芬太尼组的平均动脉血压明显低于对照组(P = 0.001)。结论:异丙酚或咪达唑仑联合芬太尼可有效镇静上消化道内窥镜下晚期肝病患者。该试验已在ClinicalTrials.gov注册,注册号:NCT03063866。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease.

Objectives: We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy.

Methods: A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group. All patients were subjected to history taking, estimation of level of sedation, endoscopist rating, and hemodynamic parameters including oxygen saturation, heart rate, mean arterial pressure, incidence of side effect as (bradycardia, hypotension, hypoxia, nausea and vomiting, cough, shivering, or diplopia), time needed for complete recovery, and time needed for discharge.

Results: There was no statistical significant difference between the studied groups regarding age, sex, weight, Child-Pugh classification score, type and duration of endoscopic intervention, time needed for complete recovery, or time needed for discharge. Complication rates were similar in both groups except for mean arterial blood pressure which was significantly lower in group of patients receiving propofol and fentanyl (P = 0.001).

Conclusion: The use of either propofol or midazolam in combination to fentanyl is effective in sedation of patients with advanced liver diseases presented for upper GIT endoscope. The trial is registered with ClinicalTrials.gov Identifier: NCT03063866.

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来源期刊
International Journal of Hepatology
International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.80
自引率
0.00%
发文量
11
审稿时长
15 weeks
期刊介绍: International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.
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