葡萄低聚茋类化合物通过抑制NF-κB活化对lps刺激的RAW 264.7巨噬细胞的抗炎作用。

Q1 Chemistry Chemistry Central Journal Pub Date : 2018-02-13 DOI:10.1186/s13065-018-0386-5
Do Thi Ha, Phung Thanh Long, Tran Thi Hien, Dao Trong Tuan, Nguyen Thi Thuy An, Nguyen Minh Khoi, Ha Van Oanh, Tran Manh Hung
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引用次数: 13

摘要

背景:越南葡萄广泛分布在越南北部,在越南传统医学中被用作治疗关节炎、支气管炎、痈和炎症以及月经不规律的药物。然而,对其化学成分和生物学作用,特别是抗炎作用的研究尚未见报道。结果:采用生物测定法对葡萄属植物气相部位的乙酸乙酯可溶性组分进行分离,分离得到一系列低聚茋类化合物,分别为杉木酸酯(1)、2-r-葡萄籽素(2)、betulifol a(3)、葡萄籽醇C(4)、(-)-反式-ε-葡萄籽素(5)、α-葡萄籽素(6)、shoreaketon(7)、amurensin B(8)、葡萄籽醇B(9)、顺式-葡萄籽素B(10)。化合物5通过抑制lps诱导的COX-2的表达和PGE2的产生,显示出最强的抑制活性。该化合物以剂量依赖性的方式显着减少lps诱导的一氧化氮(NO)释放。这些作用伴随着抑制转录因子NF-κB的激活。结论:trans-ε- vinifin通过抑制RAW 264.7细胞NF-κB活化发挥抗炎作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-κB activation.

Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property.

Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-κB activation.

Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-κB activation in RAW 264.7 cells.

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来源期刊
Chemistry Central Journal
Chemistry Central Journal 化学-化学综合
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
3.5 months
期刊介绍: BMC Chemistry is an open access, peer reviewed journal that considers all articles in the broad field of chemistry, including research on fundamental concepts, new developments and the application of chemical sciences to broad range of research fields, industry, and other disciplines. It provides an inclusive platform for the dissemination and discussion of chemistry to aid the advancement of all areas of research. Sections: -Analytical Chemistry -Organic Chemistry -Environmental and Energy Chemistry -Agricultural and Food Chemistry -Inorganic Chemistry -Medicinal Chemistry -Physical Chemistry -Materials and Macromolecular Chemistry -Green and Sustainable Chemistry
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