乳腺癌患者发生第二原发女性生殖器恶性肿瘤的风险:一项SEER分析。

IF 3 4区 医学 Q3 Biochemistry, Genetics and Molecular Biology Hormones & Cancer Pub Date : 2018-06-01 Epub Date: 2018-03-19 DOI:10.1007/s12672-018-0330-0
Zhiyu Li, Qi Wu, Junlong Song, Yimin Zhang, Shan Zhu, Shengrong Sun
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引用次数: 20

摘要

乳腺癌幸存者患第二原发癌症的风险增加,后者的风险因素可能具有临床意义。本研究的目的是评估乳腺癌幸存者中第二原发性女性生殖器官癌(子宫体、子宫子和卵巢)的发病率和危险因素。使用监测、流行病学和最终结果(SEER)数据库,我们检查了2000年至2014年间观察到的第二原发性女性生殖器癌的标准化发病率(SIR)和危险因素。乳腺癌幸存者的第二胎子宫癌和第二卵巢癌的SIR增加,第二子宫颈癌的SIR降低(SIR分别为1.17、1.12和0.64)。第二胎子宫癌的危险因素为首次诊断的年龄、种族(黑人vs白人,aHR = 1.142 95% CI 1.005-1.298)和孕激素受体(PR)状态(PR+ vs PR-, aHR = 1.131 95% CI 1.004-1.273)。此外,第二卵巢癌的风险与年龄呈正相关,与种族(黑人vs白人,aHR = 0.691 95% CI 0.555-0.859)和雌激素受体(ER)状态(ER+ vs ER-, aHR = 0.655 95% CI 0.544-0.788)呈负相关。年龄、种族和激素受体状态是乳腺癌幸存者发生第二女性生殖器癌的危险因素。年龄较大,黑人种族和幸存者的PR+状态与第二胎子宫癌的高风险相关。此外,年龄较大和ER-状态应提高对潜在的第二卵巢癌的警惕。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Risk of Second Primary Female Genital Malignancies in Women with Breast Cancer: a SEER Analysis.

Breast cancer survivors are at an increased risk of second primary cancers, and the risk factors for the latter may have clinical significance. The aims of our study were to evaluate the incidences and risk factors of second primary female genital cancers (corpus uteri, cervix uteri plus ovary) in a large cohort of breast cancer survivors. Using the Surveillance, Epidemiology, and End Results (SEER) database, we examined the standardized incidence ratio (SIR) and risk factors for second primary female genital cancers observed between 2000 and 2014. Breast cancer survivors had increased SIRs for second corpus uteri cancers and second ovarian cancers and a decreased SIR for second cervical cancers (SIR 1.17, 1.12, and 0.64, respectively). Risk factors of second corpus uteri cancers were the age at first cancer diagnosis, race (black vs. white, aHR = 1.142 95% CI 1.005-1.298), and progesterone receptor (PR) status (PR+ vs. PR-, aHR = 1.131 95% CI 1.004-1.273). In addition, the risk of second ovarian cancer was positively associated with age while inversely associated with race (black vs. white, aHR = 0.691 95% CI 0.555-0.859) and estrogen receptor (ER) status (ER+ vs. ER-, aHR = 0.655 95% CI 0.544-0.788). Age, race, and hormone receptor status are risk factors of developing second female genital cancers among breast cancer survivors. Older age, black race, and a PR+ status in survivors are associated with a higher risk of second corpus uteri cancers. Additionally, older age and an ER- status should increase vigilance for potential second ovarian cancers.

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来源期刊
Hormones & Cancer
Hormones & Cancer ONCOLOGY-ENDOCRINOLOGY & METABOLISM
CiteScore
4.60
自引率
0.00%
发文量
0
期刊介绍: Hormones and Cancer is a unique multidisciplinary translational journal featuring basic science, pre-clinical, epidemiological, and clinical research papers. It covers all aspects of the interface of Endocrinology and Oncology. Thus, the journal covers two main areas of research: Endocrine tumors (benign & malignant tumors of hormone secreting endocrine organs) and the effects of hormones on any type of tumor. We welcome all types of studies related to these fields, but our particular attention is on translational aspects of research. In addition to basic, pre-clinical, and epidemiological studies, we encourage submission of clinical studies including those that comprise small series of tumors in rare endocrine neoplasias and/or negative or confirmatory results provided that they significantly enhance our understanding of endocrine aspects of oncology. The journal does not publish case studies.
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